Título
Vaccines Directed Against Microorganisms or Their Products Present During Biofilm Lifestyle: Can We Make a Translations as a Broad Biological Model to Tuberculosis?
Autor
MARIO ALBERTO FLORES VALDEZ
Nivel de Acceso
Acceso Abierto
Referencia de publicación
URL/www.frontiersin.org
Referencia de datos
doi: 10.3389/fmicb.2016.00014
Materias
Resumen o descripción
Tuberculosis (TB) remains as a global public health problem. In recent years, experimental evidence suggesting the relevance of in vitro pellicle (a type of biofilm formed at the air-liquid interface) production as a phenotype mimicking aspects found by Mycobacterium tuberculosis-complex bacteria during in vivo infection has started to accumulate. There are still opportunities for better diagnostic tools, therapeutic molecules as well as new vaccine candidates to assist in TB control programs worldwide and particularly in less developed nations. Regarding vaccines, despite the availability of a live, attenuated strain (Mycobacterium bovis BCG) since almost a century ago, its variable efficacy and lack of protection against pulmonary and latent disease has prompted basic and applied research leading to preclinical and clinical evaluation of up to 15 new candidates. In this work, I present examples of vaccines based on whole cells grown as biofilms, or specific proteins expressed under such condition, and the effect they have shown in relevant animal models or directly in the natural host. I also discuss why it might be worthwhile to explore these approaches, for constructing and developing new vaccine candidates for testing their efficacy against TB.
Editor
Saleh AlGhamdi, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia
Fecha de publicación
21 de enero de 2016
Tipo de publicación
Artículo
Recurso de información
Formato
application/pdf
Fuente
Frontiers in Microbiology January 2016 Volume 7 Article 14
Idioma
Inglés
Audiencia
Beneficiarios de fondos federales y solicitantes
Bibliotecarios
Empresas
Estudiantes
Investigadores
Maestros
Medios de comunicación
Proveedores de fondos para estudiantes
Público en general
Sugerencia de citación
Flores-Valdez MA. Vaccines Directed Against Microorganisms or Their Products Present During Biofilm Lifestyle: Can We Make a Translation as a Broad Biological Model to Tuberculosis? Frontiers in Microbiology. 2016;7:14. doi:10.3389/fmicb.2016.00014.
Repositorio Orígen
Repositorio Institucional de CIATEJ
Descargas
486