Título
Subchronic Toxicological Evaluation of Eupatorium Aschenbornianum in Wistar Rats
Autor
Eduardo Padilla Camberos
OFELIA FERNANDEZ FLORES
Alejandro Arturo Canales Aguirre
JOSE MIGUEL FLORES FERNANDEZ
Nivel de Acceso
Acceso Abierto
Resumen o descripción
"Eupatorium aschenbornianum is a plant used for the treatment of gastric ulcer, therefore, the present study aimed to evaluate the safety of this dehydrated plant in order to find the appropriate doses for further human studies. Male Wistar rats were fed with different incremental doses dehydrated plant from 200 to 1000 mg/kg bw in a subchronic test during 45 days. Animals were sacrificed, then the clinical, hematological and biochemical changes were assessed and compared with the control group. The behavior, weight and feed consumption of the rats was normal. Also the biochemical parameters were normal except the uric acid and glutamic oxaloacetic transaminase showing elevated levels in the group treated with the highest dose. The dose of 800 mg/kg bw could be considered as no observed adverse effect level and could be used in further clinical trials in a safe manner".
Editor
International Organization of Scientific Research
Fecha de publicación
2016
Tipo de publicación
Artículo
Recurso de información
Formato
application/pdf
Fuente
IOSR Journal of Environmental Science, Toxicology and Food Technology (IOSR-JESTFT) e-ISSN: 2319-2402,p- ISSN: 2319-2399.Volume 10, Issue 10 Ver. II (Oct. 2016), PP 01-03
Idioma
Inglés
Repositorio Orígen
Repositorio Institucional de CIATEJ
Descargas
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