Título

New transgenic models of Parkinson"s disease using genome editing technology.

Autor

José Agustín Cota Coronado

SERGIO SANDOVAL AVILA

YERENDIRA PAOLAH GAYTAN DAVILA

NESTOR FABIAN DIAZ MARTINEZ

BRENDA VEGA RUIZ

Eduardo Padilla Camberos

NESTOR EMMANUEL DIAZ MARTINEZ

Nivel de Acceso

Acceso Abierto

Licencia

http://creativecommons.org/licenses/by-nc-nd/4.0

Identificador alterno

doi: https://doi.org/10.1016/j.nrl.2017.08.009

Materias

MEDICINA Y CIENCIAS DE LA SALUD - (CTI) MEDICINA Y CIENCIAS DE LA SALUD - (CTI)

Resumen o descripción

"Introduction: Parkinson’s disease (PD) is the second most common neurodegenerative disorder. It is characterised by selective loss of dopaminergic neurons in the substantia nigra pars compacta, which results in dopamine depletion, leading to a number of motor and non-motor symptoms.

Development: In recent years, the development of new animal models using nuclease-based genome-editing technology (ZFN, TALEN, and CRISPR/Cas9 nucleases) has enabled the introduction of custom-made modifications into the genome to replicate key features of PD, leading to significant advances in our understanding of the pathophysiology of the disease.

Conclusions: We review the most recent studies on this new generation of in vitro and in vivo PD models, which replicate the most relevant symptoms of the disease and enable better understanding of the aetiology and mechanisms of PD. This may be helpful in the future development of effective treatments to halt or slow disease progression."

Editor

Spanish Neurology Society

Fecha de publicación

2017

Tipo de publicación

Artículo

Recurso de información

http://ciatej.repositorioinstitucional.mx/jspui/handle/1023/705

Formato

application/pdf

Fuente

Neurologia (Barcelona, Spain), S0213-4853(17)30306-7. Advance online publication.

Idioma

Inglés

Relación

&

Díaz-Martínez, N. E. (2017). New transgenic models of Parkinson's disease using genome editing technology. Nuevos modelos transgénicos para el estudio de la enfermedad de Parkinson basados en sistemas de edición con nucleasas. Neurologia (Barcelona, Spain), S0213-4853(17)30306-7. Advance online publication.

Audiencia

Bibliotecarios

Estudiantes

Investigadores

Sugerencia de citación

Cota-Coronado, J. A., Sandoval-Ávila, S., Gaytan-Dávila, Y. P., Diaz, N. F., Vega-Ruiz, B., Padilla-Camberos, E.,

Repositorio Orígen

Repositorio Institucional de CIATEJ

Descargas

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