Título

The Neuroprotective Effect of Erythropoietin in Rat Hippocampus in an Endotoxic Shock Model

Autor

TANIA ZENTENO SAVIN

BLANCA MIRIAM DE GUADALUPE TORRES MENDOZA

OSCAR KURT BITZER QUINTERO

Luis Javier Ramírez Jirano

Ramón Gaxiola Robles

Elsy Janeth Ramos González

Nivel de Acceso

Acceso Abierto

Licencia

http://creativecommons.org/licenses/by-nc-nd/4.0

Referencia de publicación

ISSN/ISSN: 2564-8896

URL/URL: http://clinicalandtranslationalinvestigation.com

Materias

Erythropoietin, Endotoxic shock, Neuroimmunology, Neuroinflammation, Oxidative stress - (AUTOR) MEDICINA Y CIENCIAS DE LA SALUD - (CTI) CIENCIAS MÉDICAS - (CTI) PATOLOGÍA - (CTI) NEUROPATOLOGÍA - (CTI) NEUROPATOLOGÍA - (CTI)

Resumen o descripción

"Sepsis is characterized by an early systemic inflammation in response to infection. In the brain, inflammation is associated with expression of pro-inflammatory cytokines (e.g. tumor necrosis factor-α, interleukin-1β and interleukin-6, among others) that may induce an overproduction of reactive oxygen and nitrogen species. The constitutive expression of cytokines in the brain is low, but may be induced by various stimuli, including lipopolysaccharide, which causes neuronal damage. Erythropoietin, among other effects, acts as a multifunctional neurotrophic factor implicated in neurogenesis, angiogenesis, vascular permeability, and immune regulation in the central nervous system. In an experimental model of endotoxic shock, we studied the neuroprotective capacity of erythropoietin in the rat hippocampus and compared with melatonin, a neurohormone with an important antioxidant and immunomodulatory effect. Methods: In 21-day-old male Wistar rats divided into eight groups, we administered by intraperitoneal injection lipopolysaccharide, erythropoietin, melatonin, or combinations thereof. The hippocampus was dissected and morphological (histological analysis) and biochemical (cytokine levels) studies were conducted. Results: The number of dead neuronal cells in histological sections in groups treated with lipopolysaccharide was higher compared to the erythropoietin group. There was a greater decrease (70%) in interleukin-1β concentrations in rats with endotoxic shock that received erythropoietin compared to the lipopolysaccharide group."

Editor

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

Fecha de publicación

2016

Tipo de publicación

Artículo

Versión de la publicación

Versión publicada

Recurso de información

http://cibnor.repositorioinstitucional.mx/jspui/handle/1001/761

Formato

application/pdf

Fuente

REVISTA DE INVESTIGACIÓN CLÍNICA

Idioma

Inglés

Repositorio Orígen

Repositorio Institucional CIBNOR

Descargas

441