Título
A Perspective on the Development of Plant-Made vaccines in the Fight against ebola virus
Autor
SERGIO ROSALES MENDOZA
RICARDO NIETO GOMEZ
CARLOS ELIUD ANGULO VALADEZ
Nivel de Acceso
Acceso Abierto
Referencia de publicación
ISSN/ISSN: 1664-3224
URL/URL: https://www.frontiersin.org/journals/immunology
doi: DOI: 10.3389/fimmu.2017.00252
Materias
Resumen o descripción
"The Ebola virus (EBOV) epidemic indicated a great need for prophylactic and therapeutic strategies. The use of plants for the production of biopharmaceuticals is a concept being adopted by the pharmaceutical industry, with an enzyme for human use currently commercialized since 2012 and some plant-based vaccines close to being commercialized. Although plant-based antibodies against EBOV are under clinical evaluation, the development of plant-based vaccines against EBOV essentially remains an unexplored area. The
current technologies for the production of plant-based vaccines include stable nuclear expression, transient expression mediated by viral vectors, and chloroplast expression. Specific perspectives on how these technologies can be applied for developing anti- EBOV vaccines are provided, including possibilities for the design of immunogens as well as the potential of the distinct expression modalities to produce the most relevant EBOV antigens in plants considering yields, posttranslational modifications, production time, and downstream processing."
Editor
Frontiers Media, S. A.
Fecha de publicación
2017
Tipo de publicación
Artículo
Versión de la publicación
Versión publicada
Recurso de información
Formato
application/pdf
Fuente
Frontiers in Immunology
Idioma
Inglés
Sugerencia de citación
Rosales-Mendoza S, Nieto-Gómez R and Angulo C (2017) A Perspective on the Development of Plant-Made Vaccines in the Fight against Ebola Virus. Front. Immunol. 8:252
Repositorio Orígen
Repositorio Institucional CIBNOR
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