Título
In vitro and in vivo trypanocidal activity of native plants from the Yucatan Peninsula
Autor
LUIS MANUEL PEÑA RODRIGUEZ
Nivel de Acceso
Acceso Abierto
Resumen o descripción
Ethanol extracts of Senna villosa, Serjania
yucatanensis, Byrsonima bucidaefolia, and Bourreria pulchra were evaluated for their in vitro activity against
epimastigotes and trypomastigotes ofTrypanosoma cruzi.
Results showed that the leaf extracts ofS. yucatanensisand
B. pulchra were the most active against epimastigotes
(IC100=100μg/mL) and trypomastigotes ofT. cruzi(95%
or more reduction in the number of parasites at 100 and
50μg/mL). However, only the leaf extract ofS. yucatanensisshowed significant trypanocidal activity when tested
in vivo, reducing 75% of the parasitemia in infected mice at
100 mg/kg. This same extract inhibited the egress of
trypomastigotes from infected cells and proved not to be
cytotoxic (IC50=318.8±2.3μg/mL).
Fecha de publicación
2 de enero de 2012
Tipo de publicación
Artículo
Recurso de información
Formato
application/pdf
Repositorio Orígen
Repositorio Institucional CICY
Descargas
756