Título
The Leishmanicidal Effect of (3S)-16,17Didehydrofalcarinol, an Oxylipin Isolated from Tridax procumbens, is Independent of NO Production
Autor
SERGIO RUBEN PERAZA SANCHEZ
Nivel de Acceso
Acceso Abierto
Resumen o descripción
The in vitro leishmanicidal effect of (3S)-16,17-didehydrofalcarinol (1) isolated from Tridax procumbens whole
plant against Leishmania mexicana, the causative agent of cutaneous leishmaniasis (chiclero’s ulcer) in the
New World, was investigated. This oxylipin showed signifi cant in vitro activity against promastigotes and intracellular
amastigotes of L.
mexicana.
Its inhibitory effect on amastigotes was not due to activation
of NO in
recombinant
γ-interferon-stimulated
macrophages,
since the production of NO was decreased
in presence
of
the oxylipin. This is the fi rst report on the leishmanicidal activity against the intracellular stage (amastigote) of
the oxylipin (3S)-16,17-didehydrofalcarinol.
Fecha de publicación
24 de enero de 2010
Tipo de publicación
Artículo
Recurso de información
Formato
application/pdf
Idioma
Inglés
Repositorio Orígen
Repositorio Institucional CICY
Descargas
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