Título
Antigiardial activity of flavonoids from leaves of Aphelandra scabra
Autor
SERGIO RUBEN PERAZA SANCHEZ
Colaborador
GLORIA IVONNE HERNANDEZ BOLIO (Colaborador)
LUIS WILIUNFO TORRES TAPIA (Colaborador)
ROSA ESTHER MOO PUC (Colaborador)
Nivel de Acceso
Acceso Abierto
Referencia de datos
doi: DOI: 10.1016/j.bjp.2015.04.004
Materias
Resumen o descripción
Aphelandra scabra (Vahl) Sm., Acanthaceae, is a shrub widely used by some Mayan communities as carminative, antidote, and remedy for some infections. Bio-guided isolation of the methanol extract of leaves led us to the purification of the anti-giardial metabolites cirsimaritin and sorbifolin, along with the inactive metabolites cirsimarin, sorbifolin-6-O-β-glucopyranoside, and squalene. Cirsimaritin displayed high activity in the anti-giardial bioassay with an IC50 = 3.8 µM, being considered as outstanding when compared to previous reported metabolites, while sorbifolin showed a low activity with an IC50 = 75.6 µM. Additionally, both compounds proved not to be cytotoxic in an in vitro bioassay against HEK-293, a normal cell line. This is the first investigation on anti-giardial properties of A. scabra and its phytochemistry as well, thus the isolated compounds are considered as new for the plant genus and for the species.
Fecha de publicación
1 de mayo de 2015
Tipo de publicación
Artículo
Versión de la publicación
Versión publicada
Recurso de información
Formato
application/pdf
Fuente
Brazilian Journal of Pharmacognosy. 25(3), 233-237, 2015
Idioma
Inglés
Relación
&
Peraza-Sánchez, S. R. (2015). Antigiardial activity of flavonoids from leaves of aphelandra scabra. Brazilian Journal of Pharmacognosy, 25(3), 233-237. doi:10.1016/j.bjp.2015.04.004
Sugerencia de citación
Hernández-Bolio, G. I., Torres-Tapia, L. W., Moo-Puc, R.,
Repositorio Orígen
Repositorio Institucional CICY
Descargas
501