Título

Antigiardial activity of flavonoids from leaves of Aphelandra scabra

Autor

SERGIO RUBEN PERAZA SANCHEZ

Colaborador

GLORIA IVONNE HERNANDEZ BOLIO (Colaborador)

LUIS WILIUNFO TORRES TAPIA (Colaborador)

ROSA ESTHER MOO PUC (Colaborador)

Nivel de Acceso

Acceso Abierto

Referencia de datos

doi: DOI: 10.1016/j.bjp.2015.04.004

Resumen o descripción

Aphelandra scabra (Vahl) Sm., Acanthaceae, is a shrub widely used by some Mayan communities as carminative, antidote, and remedy for some infections. Bio-guided isolation of the methanol extract of leaves led us to the purification of the anti-giardial metabolites cirsimaritin and sorbifolin, along with the inactive metabolites cirsimarin, sorbifolin-6-O-β-glucopyranoside, and squalene. Cirsimaritin displayed high activity in the anti-giardial bioassay with an IC50 = 3.8 µM, being considered as outstanding when compared to previous reported metabolites, while sorbifolin showed a low activity with an IC50 = 75.6 µM. Additionally, both compounds proved not to be cytotoxic in an in vitro bioassay against HEK-293, a normal cell line. This is the first investigation on anti-giardial properties of A. scabra and its phytochemistry as well, thus the isolated compounds are considered as new for the plant genus and for the species.

Fecha de publicación

1 de mayo de 2015

Tipo de publicación

Artículo

Versión de la publicación

Versión publicada

Formato

application/pdf

Fuente

Brazilian Journal of Pharmacognosy. 25(3), 233-237, 2015

Idioma

Inglés

Relación

&

Peraza-Sánchez, S. R. (2015). Antigiardial activity of flavonoids from leaves of aphelandra scabra. Brazilian Journal of Pharmacognosy, 25(3), 233-237. doi:10.1016/j.bjp.2015.04.004

Sugerencia de citación

Hernández-Bolio, G. I., Torres-Tapia, L. W., Moo-Puc, R.,

Repositorio Orígen

Repositorio Institucional CICY

Descargas

501

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