Título
Bioactive Metabolites from Cnidoscolus souzae and Acmella pilosa
Autor
LUIS MANUEL PEÑA RODRIGUEZ
Nivel de Acceso
Acceso Abierto
Resumen o descripción
The bioassay-guided purification of the ethanol extracts of Acmella pilosa and Cnidoscolus souzae, two plants of the native flora of the Yucatan Peninsula used
in traditional medicine to treat inflammation and pain, resulted in the identification of rosmarinic acid (1) and caffeic acid (2) as the bioactive metabolites from
A. pilosa, and of 7-deoxynimbidiol (4) as the major bioactive metabolite from C. souzae. Metabolites 1, 2, and 4 proved to be responsible for the antioxidant
activity originally detected in the corresponding organic crude extracts; 7-deoxynimbidiol (4) showed good analgesic and anti-inflammatory activities,
inhibiting the pain induced by PGE2 and reducing the edema induced by carrageenan, respectively.
Fecha de publicación
14 de septiembre de 2014
Tipo de publicación
Artículo
Recurso de información
Formato
application/pdf
Repositorio Orígen
Repositorio Institucional CICY
Descargas
1891