Título

Fibrillarin from Archaea to human

Autor

ULISES RODRIGUEZ CORONA

MARGARITA SOBOL

LUIS CARLOS RODRIGUEZ ZAPATA

PAVEL HOZAK

ENRIQUE CASTAÑO DE LA SERNA

Nivel de Acceso

Acceso Abierto

Referencia de datos

datasetDOI/DOI: 10.1111/boc.201400077

Resumen o descripción

Fibrillarin is an essential protein that is well known as a molecular marker of transcriptionally active RNA polymerase I. Fibrillarin methyltransferase activity is the primary known source of methylation for more than 100 methylated sites involved in the first steps of preribosomal processing and required for structural ribosome stability. High expression levels of fibrillarin have been observed in several types of cancer cells, particularly when p53 levels are reduced, because p53 is a direct negative regulator of fibrillarin transcription. Here, we show fibrillarin domain conservation, structure and interacting molecules in different cellular processes as well as with several viral proteins during virus infection.

Fecha de publicación

2015

Tipo de publicación

Artículo

Versión de la publicación

Versión publicada

Formato

application/pdf

Fuente

Biology of the Cell, 107(6), 159-174, 2015

Idioma

Inglés

Relación

&

Castano, E. (2015). Fibrillarin from Archaea to human. Biology of the Cell, 107(6), 159-174.

Sugerencia de citación

Rodriguez‐Corona, U., Sobol, M., Rodriguez‐Zapata, L. C., Hozak, P.,

Repositorio Orígen

Repositorio Institucional CICY

Descargas

2

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