Título
Fibrillarin from Archaea to human
Autor
ULISES RODRIGUEZ CORONA
MARGARITA SOBOL
LUIS CARLOS RODRIGUEZ ZAPATA
PAVEL HOZAK
ENRIQUE CASTAÑO DE LA SERNA
Nivel de Acceso
Acceso Abierto
Referencia de datos
datasetDOI/DOI: 10.1111/boc.201400077
Materias
Resumen o descripción
Fibrillarin is an essential protein that is well known as a molecular marker of transcriptionally active RNA polymerase I. Fibrillarin methyltransferase activity is the primary known source of methylation for more than 100 methylated sites involved in the first steps of preribosomal processing and required for structural ribosome stability. High expression levels of fibrillarin have been observed in several types of cancer cells, particularly when p53 levels are reduced, because p53 is a direct negative regulator of fibrillarin transcription. Here, we show fibrillarin domain conservation, structure and interacting molecules in different cellular processes as well as with several viral proteins during virus infection.
Fecha de publicación
2015
Tipo de publicación
Artículo
Versión de la publicación
Versión publicada
Recurso de información
Formato
application/pdf
Fuente
Biology of the Cell, 107(6), 159-174, 2015
Idioma
Inglés
Relación
&
Castano, E. (2015). Fibrillarin from Archaea to human. Biology of the Cell, 107(6), 159-174.
Sugerencia de citación
Rodriguez‐Corona, U., Sobol, M., Rodriguez‐Zapata, L. C., Hozak, P.,
Repositorio Orígen
Repositorio Institucional CICY
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