Título
Oxidative stress response to menadione and cumene hydroperoxide in the opportunistic fungal pathogen Candida glabrata
Autor
MAYRA CUELLAR CRUZ
IRENE BEATRIZ CASTAÑO NAVARRO
OMAR ELIND ARROYO HELGUERA
ALEJANDRO DE LAS PEÑAS NAVA
Nivel de Acceso
Acceso Abierto
Identificador alterno
doi: http://dx.doi.org/10.1590/S0074-02762009000400020
Materias
Resumen o descripción
"Candida glabrata is an opportunistic fungal pathogen that can cause severe invasive infections and can evade phagocytic cell clearance. We are interested in understanding the virulence of this fungal pathogen, in particular its oxidative stress response. Here we investigated C. glabrata, Saccharomyces cerevisiae and Candida albicans responses to two different oxidants: menadione and cumene hydroperoxide (CHP). In log-phase, in the presence of menadione, C. glabrata requires Cta1p (catalase), while in a stationary phase (SP), Cta1p is dispensable. In addition, C. glabrata is less resistant to menadione than C. albicans in SP. The S. cerevisiae laboratory reference strain is less resistant to menadione than C. glabrata and C. albicans; however S. cerevisiaeclinical isolates (CIs) are more resistant than the lab reference strain. Furthermore, S. cerevisiae CIs showed an increased catalase activity. Interestingly, in SP C. glabrata and S. cerevisiae are more resistant to CHP than C. albicans and Cta1p plays no apparent role in detoxifying this oxidant."
Editor
Instituto Oswaldo Cruz
Fecha de publicación
julio de 2009
Tipo de publicación
Artículo
Versión de la publicación
Versión publicada
Recurso de información
Formato
application/pdf
Idioma
Inglés
Relación
&
De Las Peñas, Alejandro. (2009). Oxidative stress response to menadione and cumene hydroperoxide in the opportunistic fungal pathogen Candida glabrata. Memórias do Instituto Oswaldo Cruz, 104(4), 649-654
Audiencia
Público en general
Sugerencia de citación
Cuéllar-Cruz, Mayra, Castaño, Irene, Arroyo-Helguera, Omar,
Repositorio Orígen
Repositorio IPICYT
Descargas
444