Título

Oxidative stress response to menadione and cumene hydroperoxide in the opportunistic fungal pathogen Candida glabrata

Autor

MAYRA CUELLAR CRUZ

IRENE BEATRIZ CASTAÑO NAVARRO

OMAR ELIND ARROYO HELGUERA

ALEJANDRO DE LAS PEÑAS NAVA

Nivel de Acceso

Acceso Abierto

Identificador alterno

doi: http://dx.doi.org/10.1590/S0074-02762009000400020

Resumen o descripción

"Candida glabrata is an opportunistic fungal pathogen that can cause severe invasive infections and can evade phagocytic cell clearance. We are interested in understanding the virulence of this fungal pathogen, in particular its oxidative stress response. Here we investigated C. glabrata, Saccharomyces cerevisiae and Candida albicans responses to two different oxidants: menadione and cumene hydroperoxide (CHP). In log-phase, in the presence of menadione, C. glabrata requires Cta1p (catalase), while in a stationary phase (SP), Cta1p is dispensable. In addition, C. glabrata is less resistant to menadione than C. albicans in SP. The S. cerevisiae laboratory reference strain is less resistant to menadione than C. glabrata and C. albicans; however S. cerevisiaeclinical isolates (CIs) are more resistant than the lab reference strain. Furthermore, S. cerevisiae CIs showed an increased catalase activity. Interestingly, in SP C. glabrata and S. cerevisiae are more resistant to CHP than C. albicans and Cta1p plays no apparent role in detoxifying this oxidant."

Editor

Instituto Oswaldo Cruz

Fecha de publicación

julio de 2009

Tipo de publicación

Artículo

Versión de la publicación

Versión publicada

Formato

application/pdf

Idioma

Inglés

Relación

&

De Las Peñas, Alejandro. (2009). Oxidative stress response to menadione and cumene hydroperoxide in the opportunistic fungal pathogen Candida glabrata. Memórias do Instituto Oswaldo Cruz, 104(4), 649-654

Audiencia

Público en general

Sugerencia de citación

Cuéllar-Cruz, Mayra, Castaño, Irene, Arroyo-Helguera, Omar,

Repositorio Orígen

Repositorio IPICYT

Descargas

444

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