Título

Simple approach for ranking structure determining residues

Autor

OSCAR DANIEL LUNA MARTINEZ

ABRAHAM MARCELINO VIDAL LIMON

MIRYAM IVETTE VILLALBA VELAZQUEZ

RAMON GARDUÑO JUAREZ

Vladimir Uversky

BALTAZAR BECERRIL LUJAN

Nivel de Acceso

Acceso Abierto

Identificador alterno

doi: https://doi.org/10.7717/peerj.2136

Resumen o descripción

"Mutating residues has been a common task in order to study structural properties of the protein of interest. Here, we propose and validate a simple method that allows the identification of structural determinants; i.e., residues essential for preservation of the stability of global structure, regardless of the protein topology. This method evaluates all of the residues in a 3D structure of a given globular protein by ranking them according to their connectivity and movement restrictions without topology constraints. Our results matched up with sequence-based predictors that look up for intrinsically disordered segments, suggesting that protein disorder can also be described with the proposed methodology."

Editor

PeerJ, Inc

Fecha de publicación

junio de 2016

Tipo de publicación

Artículo

Versión de la publicación

Versión publicada

Formato

application/pdf

Sugerencia de citación

Luna-Martínez OD, Vidal-Limón A, Villalba-Velázquez MI, Sánchez-Alcalá R, Garduño-Juárez R, Uversky VN, Becerril B. (2016) Simple approach for ranking structure determining residues. PeerJ 4:e2136 https://doi.org/10.7717/peerj.2136

Repositorio Orígen

Repositorio IPICYT

Descargas

285

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