Título

Identification of differential expressed transcripts in cervical cancer of Mexican patients

Autor

MARTHA LETICIA SANTOS MARTINEZ

Ma. Fabiola León Galván

ERIKA NAHOMY MARINO MARMOLEJO

Ana Paulina Barba de la Rosa

Antonio de León Rodríguez

Roberto Fidencio González Amaro

Ramón Gerardo Guevara González

Nivel de Acceso

Acceso Abierto

Identificador alterno

doi: https://doi.org/10.1007/s13277-010-0151-4

Resumen o descripción

"The aim of this study was to identify the gene expression profile in biopsies of patients with cervical intraepithelial neoplasia (CIN) 1, CIN 2, CIN 3, and microinvasive cancer by suppression subtractive hybridization and Southern blotting. After analyzing 1,800 cDNA clones, we found 198 upregulated genes, 166 downregulated, and no significant change of gene expression in 86 clones (p = 0.005). These results were validated by Northern blot analysis (p = 0.0001) in the identification of 28 overexpressed and 7 downregulated transcripts. We observed a set of genes related to the Notch signaling pathway that may be involved in the transformation of cervical cells and in the development to malignancy. The differentially expressed genes may provide useful information about the molecular mechanisms involved in human cervical carcinoma and as diagnostic markers."

Editor

Springer

Fecha de publicación

junio de 2011

Tipo de publicación

Artículo

Versión de la publicación

Versión aceptada

Formato

application/pdf

Sugerencia de citación

Santos, L., León-Galván, M.F., Marino-Marmolejo, E.N. et al. Tumor Biol. (2011) 32: 561. https://doi.org/10.1007/s13277-010-0151-4 DOI

Repositorio Orígen

Repositorio IPICYT

Descargas

368

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