Título
Identification of differential expressed transcripts in cervical cancer of Mexican patients
Autor
MARTHA LETICIA SANTOS MARTINEZ
Ma. Fabiola León Galván
ERIKA NAHOMY MARINO MARMOLEJO
Ana Paulina Barba de la Rosa
Antonio de León Rodríguez
Roberto Fidencio González Amaro
Ramón Gerardo Guevara González
Nivel de Acceso
Acceso Abierto
Identificador alterno
doi: https://doi.org/10.1007/s13277-010-0151-4
Materias
Resumen o descripción
"The aim of this study was to identify the gene expression profile in biopsies of patients with cervical intraepithelial neoplasia (CIN) 1, CIN 2, CIN 3, and microinvasive cancer by suppression subtractive hybridization and Southern blotting. After analyzing 1,800 cDNA clones, we found 198 upregulated genes, 166 downregulated, and no significant change of gene expression in 86 clones (p = 0.005). These results were validated by Northern blot analysis (p = 0.0001) in the identification of 28 overexpressed and 7 downregulated transcripts. We observed a set of genes related to the Notch signaling pathway that may be involved in the transformation of cervical cells and in the development to malignancy. The differentially expressed genes may provide useful information about the molecular mechanisms involved in human cervical carcinoma and as diagnostic markers."
Editor
Springer
Fecha de publicación
junio de 2011
Tipo de publicación
Artículo
Versión de la publicación
Versión aceptada
Recurso de información
Formato
application/pdf
Sugerencia de citación
Santos, L., León-Galván, M.F., Marino-Marmolejo, E.N. et al. Tumor Biol. (2011) 32: 561. https://doi.org/10.1007/s13277-010-0151-4 DOI
Repositorio Orígen
Repositorio IPICYT
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