Título

Amaranth supplementation prevents the increase in activity of dipeptidyl peptidase IV in plasma of streptozotocin-induced diabetic rats

Autor

AIDA JIMENA VELARDE SALCEDO

EVELYN REGALADO RENTERIA

BERTHA IRENE JUAREZ FLORES

ALBERTO BARRERA PACHECO

ANA PAULINA BARBA DE LA ROSA

Nivel de Acceso

En Embargo

Licencia

http://creativecommons.org/licenses/by-nc-nd/4.0

Identificador alterno

doi: https://doi.org/10.1159/000486482

Materias

Amaranth - (AUTOR) Bioactive peptides - (AUTOR) Diabetes - (AUTOR) Dipeptidyl peptidase IV - (AUTOR) Plasma proteomics - (AUTOR) BIOLOGÍA Y QUÍMICA - (CTI) CIENCIAS DE LA VIDA - (CTI) GENÉTICA - (CTI)

Resumen o descripción

"Scope: Amaranth grain is a source of several bioactive compounds such as cancer-preventive and ACE inhibitory peptides. In vitro analysis of amaranth proteins has also demonstrated the presence of bioactive peptides, which exert inhibitory activity upon dipeptidyl peptidase IV (DPPIV), a new target for type 2 diabetes, but this potential activity has not been tested in vivo. The aim of this work was to evaluate whether chronic amaranth consumption has a beneficial effect in streptozotocin-induced diabetic rats, particularly in DPPIV activity and changes in plasma proteome profile. Methods and results: Diabetic rats were fed with 20% popped amaranth grain diet for 12 weeks. Changes in lipid profile, DPPIV activity in plasma and kidney, as well changes in plasma proteome were evaluated. Total cholesterol and DPPIV activity in plasma were increased in diabetic rats but this was ameliorated by amaranth consumption. Diabetic rats fed with amaranth showed the highest levels of HDL and this correlated with an accumulation of apolipoprotein (apo) A-II. Furthermore, amaranth diet stimulated the up-accumulation of the antioxidant protein paraoxonase 1(PON1). Conclusion This study provides molecular evidence about the role of amaranth as a potential functional food with DPPIV inhibitory activity and with a positive effect in plasma lipoproteins."

Editor

Karger

Fecha de publicación

2017

Tipo de publicación

Artículo

Versión de la publicación

Versión enviada

Recurso de información

http://ipicyt.repositorioinstitucional.mx/jspui/handle/1010/1561

Formato

application/pdf

Sugerencia de citación

J Nutrigenet Nutrigenomics 2017;10:181–193 (DOI:10.1159/000486482)

Repositorio Orígen

Repositorio IPICYT

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