Título
Adhesins in Candida glabrata
Autor
Bea Timmermans
Alejandro de las Peñas Nava
Irene Beatriz Castaño Navarro
Patrick Van Dijck
Nivel de Acceso
Acceso Abierto
Identificador alterno
doi: https://doi.org/10.3390/jof4020060
Materias
Resumen o descripción
"The human fungal pathogen Candida glabrata is causing more and more problems in hospitals, as this species shows an intrinsic antifungal drug resistance or rapidly becomes resistant when challenged with antifungals. C. glabrata only grows in the yeast form, so it is lacking a yeast-to-hyphae switch, which is one of the main virulence factors of C. albicans. An important virulence factor of C. glabrata is its capacity to strongly adhere to many different substrates. To achieve this, C. glabrata expresses a large number of adhesin-encoding genes and genome comparisons with closely related species, including the non-pathogenic S. cerevisiae, which revealed a correlation between the number of adhesin-encoding genes and pathogenicity. The adhesins are involved in the first steps during an infection; they are the first point of contact with the host. For several of these adhesins, their importance in adherence to different substrates and subsequent biofilm formation was demonstrated in vitro or in vivo. In this review, we provide an overview of the role of C. glabrata adhesins during adhesion and biofilm formation both, under in vitro and in vivo conditions."
Editor
MDPI AG
Fecha de publicación
2018
Tipo de publicación
Artículo
Versión de la publicación
Versión publicada
Recurso de información
Formato
application/pdf
Sugerencia de citación
Timmermans, B.; De Las Peñas, A.; Castaño, I.; Van Dijck, P. Adhesins in Candida glabrata. J. Fungi 2018, 4, 60.
Repositorio Orígen
Repositorio IPICYT
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