Título
Ultraviolet-A Light Induces Micronucleated Erythrocytes in Newborn Rats
Autor
BLANCA PATRICIA LAZALDE RAMOS
Nivel de Acceso
Acceso Abierto
Materias
Resumen o descripción
Background: Ultraviolet-A (UV-A) light induce DNA damage by
creating pyrimidine dimers, or indirectly affects DNA by the formation
of reactive oxygen species. The objective was to determine DNA
damage by micronucleus test in neonatal rats exposed to UV-A
light.
Methods: Rat neonates were exposed to light from a LED
lamp (control group), to UV-C light 254 nm (control group to
desquamation skin) or UV-A light 365 nm and in one group the
dams were supplemented with folic acid (FA), to determine micro
nucleated erythrocytes (MNE) and micro nucleated polychromatic
erythrocytes (MNPCE) in peripheral blood of offspring.
Results: All the rat neonates exposed to UV-C lamp showed
desquamation skin, while for UV-A lamp no desquamation was
observed, and there was MNE differences in all sampling times
(P<0.02) and for MNPCE in 9 min group (P=0.001). No differences
between the groups with and without FA were observed.
Conclusion: Increased MNE frequencies without apparent damage
to the skin could be induced with UV-A light exposure. Under these
conditions, FA no protected against UV-A light exposure. This study
shows a manner to quantify the genotoxic effects of UV-A light in
peripheral blood erythrocytes of rat neonates.
Producción Científica de la Universidad Autónoma de Zacatecas UAZ
Fecha de publicación
8 de abril de 2016
Tipo de publicación
Artículo
Recurso de información
Formato
application/pdf
Idioma
Inglés
Audiencia
Público en general
Repositorio Orígen
Repositorio Institucional Caxcán
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