Neuropsychiatric symptoms distress comparison between caregivers of Alzheimer disease and frontolobar degeneration patients

FRANCISCO LEONARDO RAMIREZ CUAPIO; ADRIAN MARTINEZ RUIZ; Ana Luisa Sosa Ortiz

Título

Autor

FRANCISCO LEONARDO RAMIREZ CUAPIO

ADRIAN MARTINEZ RUIZ

Ana Luisa Sosa Ortiz

Nivel de Acceso

Acceso Abierto

Licencia

http://creativecommons.org/licenses/by-nc-nd/4.0

Materias

Resumen o descripción

Background

Neuropsychiatric symptoms (NPS) are common in dementia and they have an important role over the caregiver distress; the instrument most widely used to explore them is the Neuropsychiatric Inventory (NPI‐i) it includes a caregiver distress scale. The goal of this study was to identify and compare the NPS in subjects with Alzheimeŕs Disease (AD) and Frontotemporal lobar degeneration (FTLD) and analyze the distress caused for the NPS to the caregivers in different stages of the disease.

Methods

Two groups of patients were studied: one with 37 AD and other with 12 FTLD patients, assessed from January 2015 to January 2016 at the National Institute of Neurology of Mexico. The NPS and the caregiver distress were evaluated by the NPS‐i.

Results

For the whole group (N=49), the mean age was 64 years (SD ±12.8), 65% were women. None of the sociodemographic variables analyzed showed statistical significant difference. The minimental state examination (MMSE) average score was 15 (SD ±6) for the whole group, for the AD group the MMSE average score was 15 points (SD ±6) and for the FTLD group 14 points (SD ±7). Also we graded the severity of the dementia (clinical criteria and MMSE score), 16 (31%), 10 (20%) and 15 (33%) were the patients with mild, moderate and severe dementia. Regarding the presence and severity of the NPS two showed statistical differences: elation/euphoria (p=0.01 and p=0.02 for presence and severity respectively), and appetite/eating (p=0.05 and p=0.01 for presence and severity respectively). The symptoms that showed statistical significance regarding the caregiver distress between both groups were for mild dementia: elation/euphoria (p=0.008) and disinhibition(p=0.03); for moderate dementia agitation/aggression (p=0.03). For severe dementia the symptoms that had statically significant difference were: depression/dysphoria (p=0.01), aberrant motor behavior (p= 0.03), nighttime behavior (p=0.02), and appetite/eating (p=0.05).

Conclusions

What attract our attention were the differences of the symptom′s distress reported for the caregivers at the later stages of the diseases, this may be influenced by other external factors. The interest to treat the stressfulness of the caregiver is mainly to maintain the highest quality of life possible for both: patient and caregiver.

Editor

Alzheimer´s Association

Fecha de publicación

2016

Tipo de publicación

Artículo

Recurso de información

http://hdl.handle.net/20.500.12100/17140

Formato

Adobe PDF

application/pdf

Fuente

Alzheimer's and Dementia: The Journal of the Alzheimer's Association (1552-5279) vol. 12 (2016)

Idioma

Inglés

Relación

https://alz-journals.onlinelibrary.wiley.com/doi/10.1016/j.jalz.2016.06.2230

Repositorio Orígen

INSTITUTO NACIONAL DE GERIATRIA

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