Título
TBHQ induces a hormetic response that protects L6 myoblasts against the toxic effect of palmitate
Autor
PEDRO POSADAS RODRIGUEZ
NATALIA ESMERALDA POSADAS RODRIGUEZ
VIRIDIANA YAZMIN GONZALEZ PUERTOS
RAFAEL TOLEDO PEREZ
JOSE LUIS VENTURA GALLEGOS
ALEJANDRO ZENTELLA DEHESA
LUIS ENRIQUE GOMEZ QUIROZ
MINA KONIGSBERG FAINSTEIN
ARMANDO LUNA LOPEZ
Nivel de Acceso
Acceso Abierto
Materias
MEDICINA Y CIENCIAS DE LA SALUD - (CTI) Ciencias médicas - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Ciencias Clínicas - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Nutrición - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Dieta, alimentación y nutrición - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Estado nutricional - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Dieta - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Desordenes nutricionales - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Obesidad - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Personas mayores - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Longevidad - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Diet, food and nutrition - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Nutritional status - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Diet - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Nutrition disorders - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Obesity - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Elderly - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Longevity - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)])
Resumen o descripción
Nutritional status, in particular overweight and obesity, as well as sedentarism and high-fat diet consumption, are important risk factors to develop chronic diseases, which have a higher impact on the elderly’s health. Therefore, these nutritional problems have become a concern to human healthspan and longevity. The fatty acids obtained thru the diet or due to fatty acid synthesis during obesity accumulate within the body generating toxicity and cell death. Fat is not only stored in adipose tissue, but it can also be stored in skeletal muscle. Palmitic acid (PA) has been reported as one of the most important saturated free fatty acids; it is associated to chronic oxidative stress and increased mitochondrial ROS production causing cell death by apoptosis. In skeletal muscle, palmitate has been associated with various pathophysiological consequences, which lead to muscle deterioration during aging and obesity. Since molecules that modify redox state have been proven to prevent cellular damage by inducing a hormetic response, the aim of this study was to evaluate if tert-butylhydroquinone (tBHQ) could activate an antioxidant hormetic response that would be able to protect L6 myoblasts from palmitate toxic effect. Our results provide evidence that tBHQ is able to protect L6 myoblasts against the toxicity induced by sodium palmitate due to a synergistic activation of different signaling pathways such as Nrf2 and NF-κB.
Editor
Hindawi
Fecha de publicación
2020
Tipo de publicación
Artículo
Recurso de información
Formato
Adobe PDF
application/pdf
Fuente
Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)
Idioma
Inglés
Relación
https://www.hindawi.com/journals/omcl/2020/3123268/
Repositorio Orígen
INSTITUTO NACIONAL DE GERIATRIA
Descargas
0