Título

TBHQ induces a hormetic response that protects L6 myoblasts against the toxic effect of palmitate

Autor

PEDRO POSADAS RODRIGUEZ

NATALIA ESMERALDA POSADAS RODRIGUEZ

VIRIDIANA YAZMIN GONZALEZ PUERTOS

RAFAEL TOLEDO PEREZ

JOSE LUIS VENTURA GALLEGOS

ALEJANDRO ZENTELLA DEHESA

LUIS ENRIQUE GOMEZ QUIROZ

MINA KONIGSBERG FAINSTEIN

ARMANDO LUNA LOPEZ

Nivel de Acceso

Acceso Abierto

Materias

MEDICINA Y CIENCIAS DE LA SALUD - (CTI) Ciencias médicas - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Ciencias Clínicas - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Nutrición - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Dieta, alimentación y nutrición - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Estado nutricional - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Dieta - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Desordenes nutricionales - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Obesidad - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Personas mayores - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Longevidad - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Diet, food and nutrition - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Nutritional status - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Diet - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Nutrition disorders - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Obesity - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Elderly - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)]) Longevity - ([Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)])

Resumen o descripción

Nutritional status, in particular overweight and obesity, as well as sedentarism and high-fat diet consumption, are important risk factors to develop chronic diseases, which have a higher impact on the elderly’s health. Therefore, these nutritional problems have become a concern to human healthspan and longevity. The fatty acids obtained thru the diet or due to fatty acid synthesis during obesity accumulate within the body generating toxicity and cell death. Fat is not only stored in adipose tissue, but it can also be stored in skeletal muscle. Palmitic acid (PA) has been reported as one of the most important saturated free fatty acids; it is associated to chronic oxidative stress and increased mitochondrial ROS production causing cell death by apoptosis. In skeletal muscle, palmitate has been associated with various pathophysiological consequences, which lead to muscle deterioration during aging and obesity. Since molecules that modify redox state have been proven to prevent cellular damage by inducing a hormetic response, the aim of this study was to evaluate if tert-butylhydroquinone (tBHQ) could activate an antioxidant hormetic response that would be able to protect L6 myoblasts from palmitate toxic effect. Our results provide evidence that tBHQ is able to protect L6 myoblasts against the toxicity induced by sodium palmitate due to a synergistic activation of different signaling pathways such as Nrf2 and NF-κB.

Editor

Hindawi

Fecha de publicación

2020

Tipo de publicación

Artículo

Formato

Adobe PDF

application/pdf

Fuente

Oxidative Medicine and Cellular Longevity (1942-0994) Vol. 2020 (2020)

Idioma

Inglés

Relación

https://www.hindawi.com/journals/omcl/2020/3123268/

Repositorio Orígen

INSTITUTO NACIONAL DE GERIATRIA

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