Título
Allostatic Load as a Biological Substrate to Intrinsic Capacity: A Secondary Analysis of CRELES
Autor
LUIS MIGUEL FRANCISCO GUTIERREZ ROBLEDO
ROSA ESTELA GARCIA CHANES
MARIO ULISES PEREZ ZEPEDA
Nivel de Acceso
Acceso Abierto
Materias
MEDICINA Y CIENCIAS DE LA SALUD - (CTI) Ciencias médicas - ([Journal of Nutrition, Health and Aging (1760-4788) Vol. 23 (2019)]) Ciencias Clínicas - ([Journal of Nutrition, Health and Aging (1760-4788) Vol. 23 (2019)]) Geriatría - ([Journal of Nutrition, Health and Aging (1760-4788) Vol. 23 (2019)]) Mecanismos de comportamiento y comportamiento - ([Journal of Nutrition, Health and Aging (1760-4788) Vol. 23 (2019)]) Psicología social - ([Journal of Nutrition, Health and Aging (1760-4788) Vol. 23 (2019)]) Estilo de vida saludable - ([Journal of Nutrition, Health and Aging (1760-4788) Vol. 23 (2019)]) Envejecimiento saludable - ([Journal of Nutrition, Health and Aging (1760-4788) Vol. 23 (2019)]) Crecimiento y desarrollo - ([Journal of Nutrition, Health and Aging (1760-4788) Vol. 23 (2019)]) Envejecimiento - ([Journal of Nutrition, Health and Aging (1760-4788) Vol. 23 (2019)]) Capacidad intrinseca - ([Journal of Nutrition, Health and Aging (1760-4788) Vol. 23 (2019)]) Geriatrics - ([Journal of Nutrition, Health and Aging (1760-4788) Vol. 23 (2019)]) Behavior and behavior mechanisms - ([Journal of Nutrition, Health and Aging (1760-4788) Vol. 23 (2019)]) Psychology, Social - ([Journal of Nutrition, Health and Aging (1760-4788) Vol. 23 (2019)]) Healthy lifestyle - ([Journal of Nutrition, Health and Aging (1760-4788) Vol. 23 (2019)]) Healthy aging - ([Journal of Nutrition, Health and Aging (1760-4788) Vol. 23 (2019)]) Growth and development - ([Journal of Nutrition, Health and Aging (1760-4788) Vol. 23 (2019)]) Aging - ([Journal of Nutrition, Health and Aging (1760-4788) Vol. 23 (2019)]) Intrinsic capacity - ([Journal of Nutrition, Health and Aging (1760-4788) Vol. 23 (2019)])
Resumen o descripción
Objectives
Intrinsic capacity (IC) is one of the latest views of positive aging. In its current status lacks a biological substrate amenable to be intervened. The aim of this study was to determine the association of allostatic load (AL) with IC.
Design
We present a cross-sectional analysis of the Costa Rican Longevity and Healthy Aging Study.
Setting
This report is from a representative sample of Costa Rican older adults; one of the countries that integrate the Central America region.
Participants
2,827, 60-year or older community-dwelling individuals.
Methods
An IC index was gathered and validated, including different domains: cognitive, psychological, sensory, vitality and locomotion. AL was integrated with: blood pressure, abdominal obesity, body mass index, HDL-cholesterol, glycosylated hemoglobin, DHEAS, cortisol, epinephrine and norepinephrine. AL was grouped in three categories according to the number of abnormal biomarkers (0–1, 2–3 and ≥4). Chronic diseases, socioeconomic level, sex and age were the adjusting variables. Ordinal logistic regression models were estimated in order to test the strength of the association.
Results
From a total sample of 1,888 individuals, 51% (n=962) were women, 36.4% were in the 60–69 age category. The mean score of the IC index was of 6.6 (±2.2). Odds ratio (OR) of the adjusted models were significant for the group of those with 2–3 abnormal biomarkers of AL (OR 0.67, p=0.007) and also for those with ≥4 (OR 0.56, p=0.002), when compared to the reference group of AL (0–1 abnormal biomarkers).
Conclusions and implications
AL showed an incremental association with IC, even when adjusted for factors such as socioeconomic status and chronic diseases. Targeting therapeutically AL could potentially improve IC in older adults and therefore decreasing the progression to disability or to overt dependency.
Editor
Springer
&
Serdi-Editions
Fecha de publicación
2019
Tipo de publicación
Artículo
Recurso de información
Formato
Adobe PDF
application/pdf
Fuente
Journal of Nutrition, Health and Aging (1760-4788) Vol. 23 (2019)
Idioma
Inglés
Relación
https://link.springer.com/article/10.1007/s12603-019-1251-5
Repositorio Orígen
INSTITUTO NACIONAL DE GERIATRIA
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