Título
Gonadectomy and progesterone treatment induce protection in murine cysticercosis.
Autor
JOSE ANTONIO VARGAS VILLAVICENCIO
CARLOS LARRALDE RANGEL
JORGE MORALES MONTOR
Nivel de Acceso
Acceso Abierto
Materias
MEDICINA Y CIENCIAS DE LA SALUD - (CTI) Adyuvantes inmunológicos - Metabolismo - ([Parasite Immunology 28(12):667-674]) Adyuvantes inmunológicos - Farmacologia - ([Parasite Immunology 28(12):667-674]) Cisticercosis - Parasitología - ([Parasite Immunology 28(12):667-674]) Cisticercosis - Efectos de drogas - ([Parasite Immunology 28(12):667-674]) Deshidroepiandrosterona - Metabolismo - ([Parasite Immunology 28(12):667-674]) Deshidroepiandrosterona - Farmacología - ([Parasite Immunology 28(12):667-674]) Ratones consanguíneos BALB C - Ratones - ([Parasite Immunology 28(12):667-674]) Orquiectomía - ([Parasite Immunology 28(12):667-674]) Progesterona - Administración - ([Parasite Immunology 28(12):667-674]) & - ([Parasite Immunology 28(12):667-674]) dosificación - ([Parasite Immunology 28(12):667-674]) Progesterona - Metabolismo - ([Parasite Immunology 28(12):667-674]) Progesterona - Uso terapéutico - ([Parasite Immunology 28(12):667-674]) Taenia - Efectos de drogas - ([Parasite Immunology 28(12):667-674]) Taenia - Crecimiento - ([Parasite Immunology 28(12):667-674]) & - ([Parasite Immunology 28(12):667-674]) desarrollo - ([Parasite Immunology 28(12):667-674]) Resultado del tratamiento - ([Parasite Immunology 28(12):667-674]) Adjuvants, immunologic - Metabolism - ([Parasite Immunology 28(12):667-674]) Adjuvants, immunologic - Pharmacology - ([Parasite Immunology 28(12):667-674]) Cysticercosis - Immunology - ([Parasite Immunology 28(12):667-674]) Cysticercosis - Parasitology - ([Parasite Immunology 28(12):667-674]) Cysticercus - Drug effects - ([Parasite Immunology 28(12):667-674]) Dehydroepiandrosterone- Metabolism - ([Parasite Immunology 28(12):667-674]) Dehydroepiandrosterone - Pharmacology - ([Parasite Immunology 28(12):667-674]) Mice, inbred BALB C - ([Parasite Immunology 28(12):667-674]) Orchiectomy - ([Parasite Immunology 28(12):667-674]) Ovariectomy - ([Parasite Immunology 28(12):667-674]) Progesterone - Administration - ([Parasite Immunology 28(12):667-674]) & - ([Parasite Immunology 28(12):667-674]) dosage - ([Parasite Immunology 28(12):667-674]) Progesterone - Metabolism - ([Parasite Immunology 28(12):667-674]) Progesterone - Therapeutic use - ([Parasite Immunology 28(12):667-674]) Progestins - Administration - ([Parasite Immunology 28(12):667-674]) & - ([Parasite Immunology 28(12):667-674]) dosage - ([Parasite Immunology 28(12):667-674]) Progestins - Metabolism - ([Parasite Immunology 28(12):667-674]) Progestins - Therapeutic use - ([Parasite Immunology 28(12):667-674]) Taenia - Drug effects - ([Parasite Immunology 28(12):667-674]) Taenia - Growth - ([Parasite Immunology 28(12):667-674]) & - ([Parasite Immunology 28(12):667-674]) development - ([Parasite Immunology 28(12):667-674]) Treatment outcome - ([Parasite Immunology 28(12):667-674]) Cisticercosis - ([Parasite Immunology 28(12):667-674]) Inmunoendocrinos - ([Parasite Immunology 28(12):667-674]) Metabolismo - ([Parasite Immunology 28(12):667-674]) Progesterona - ([Parasite Immunology 28(12):667-674]) Cysticercosis - ([Parasite Immunology 28(12):667-674]) Immunoendocrine - ([Parasite Immunology 28(12):667-674]) Progesterone - ([Parasite Immunology 28(12):667-674]) Taenia - ([Parasite Immunology 28(12):667-674])
Resumen o descripción
The effects of progesterone on castrated mice of both sexes infected with Taenia crassiceps cysticerci were studied. Gonadectomy and treatment with progesterone before infection decreased parasite loads by 100% compared with intact uninfected mice. mRNA levels of IFN gamma and IL-2 (typically associated to Th1-like profiles) were markedly decreased in infected gonadectomized (Gx) mice, whereas progesterone treatment of infected Gx mice did not affected its expression. mRNA levels of IL-4, and IL-10 (typically associated with Th2-like profiles) were reduced by gonadectomy, whereas restitution with progesterone did not affected this pattern in infected Gx progesterone-treated mice. Infection markedly induced expression of progesterone receptor isoform A in splenocytes of Gx mice (5-fold), whereas isoform B had no changes.
Progesterone metabolism to dehydroepiandrosterone (DHEA) in Gx animals was increased 3-fold only in infected progesterone-treated uninfecteds of both sexes, but was not detectable in infected Gx progesterone-treated mice. Conversely, DHEA levels increased 100-fold in infected Gx progesterone-treated mice. However, androgen receptor expression in splenocytes of male mice showed a reduction by gonadectomy, and by infection, whereas in females AR expression showed no changes in the different mouse groups. These results suggest that progesterone, through its metabolism to DHEA, negatively affects the establishment, growth, and reproduction of Taenia crassiceps, by a mechanism that does not implicate a classic genomic pathway involving a nuclear androgen receptor.
Editor
Wiley
Fecha de publicación
2006
Tipo de publicación
Artículo
Recurso de información
http://repositorio.pediatria.gob.mx:8180/handle/20.500.12103/3118
10.1111/j.1365-3024.2006.00906.x
Formato
application/pdf
Fuente
Parasite Immunology 28(12):667-674
Idioma
Español
Repositorio Orígen
Repositorio del Instituto Nacional de Pediatría
Descargas
231