Título

Organocatalytic cascade reaction for the synthesis of polycylic compounds utilizing Trienamine activation

Autor

SUHAS BALASAHEB MITKARI

Colaborador

David Cruz Cruz (Director)

CLARISA VILLEGAS GOMEZ (Director)

Nivel de Acceso

Acceso Abierto

Licencia

http://creativecommons.org/licenses/by-nc-nd/4.0

Materias

CGU- Doctorado en Química BIOLOGÍA Y QUÍMICA - (CTI) CIENCIAS TECNOLÓGICAS - (CTI) INGENIERÍA Y TECNOLOGÍA QUÍMICAS - (CTI) Organocatalytic cascade reaction Polycylic compounds – Synthesis Trienamine - Activation

Resumen o descripción

We report an Aminocatalytic privileged Diversity-Oriented Synthesis (ApDOS) strategy via trienamine catalysis for the construction of diverse and complex thiopyrans-piperidone fused rings through a thia-Diels–Alder/nucleophilic ring closing sequence by using dithioamides as activated heterodienophiles. Following this strategy, a super cascade reaction to assemble nine fused rings can be achieved by employing a bis-dithioamide. Additionally, by linking an indole moiety on the dithioamide, a Pictet-Spengler type reaction can be promoted once the cascade sequence has been achieved, leading to more complex penta- hexa- and heptacyclic fused ring derivatives in a one-pot process. This investigation, open new perspectives for the synthesis of a new class of complex and diverse thiopyrans, which contribute to populate new relevant regions in the chemical space.

Editor

Universidad de Guanajuato

Fecha de publicación

2021

Tipo de publicación

Tesis de doctorado

Versión de la publicación

Versión publicada

Recurso de información

http://repositorio.ugto.mx/handle/20.500.12059/5166

Formato

application/pdf

Idioma

Inglés

Repositorio Orígen

Repositorio Institucional de la Universidad de Guanajuato

Descargas

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