Título
Synthesis and in vitro evaluation of an antiangiogenic cancerspecific dual-targeting 177Lu-Au-nanoradiopharmaceutical
Autor
ABRAHAM GONZALEZ RUIZ
GUILLERMINA FERRO FLORES
ERIKA PATRICIA AZORIN VEGA
BLANCA ELI OCAMPO GARCIA
FLOR DE MARIA RAMIREZ DE LA CRUZ
CLARA LETICIA SANTOS CUEVAS
Luis De León Rodríguez
KEILA ISAAC OLIVE
MYRNA ALEJANDRA LUNA GUTIERREZ
ENRIQUE MORALES AVILA
Nivel de Acceso
Acceso Abierto
Materias
Lutetium-177 - ([1588-2780, 0236-5731]) - ([1588-2780, 0236-5731]) 177Lu-gold nanoparticles - ([1588-2780, 0236-5731]) - ([1588-2780, 0236-5731]) Antiangiogenic agent - ([1588-2780, 0236-5731]) - ([1588-2780, 0236-5731]) HS-pentyl-pegaptanib - ([1588-2780, 0236-5731]) - ([1588-2780, 0236-5731]) VEGF inhibition - ([1588-2780, 0236-5731]) - ([1588-2780, 0236-5731]) BIOLOGÍA Y QUÍMICA - (CTI)
Resumen o descripción
The aim of this research was to synthesize and chemically characterize a cancer-specific 177Lu-Aunanoradiopharmaceutical based on gold nanoparticles (NPs), the nuclear localization sequence (NLS)-Arg-Gly- Asp peptide and an aptamer (HS-pentyl-pegaptanib) to target both the a(v)b(3) integrin and the vascular endothelial growth factor (VEGF) overexpressed in the tumor neovasculature, as well as to evaluate by the tube formation assay, the nanosystem capability to inhibit angiogenesis. 177Lu-NP-RGD-NLS-Aptamer was obtained with a radiochemical purity of 99 ± 1%. Complete inhibition of tube formation (angiogenesis) was demonstrated when endothelial cells (EA.hy926), cultured in a 3D-extracellular matrix support, were treated with the developed nanosystem.
Mexican National Council of Science and Technology (CONACYT-SEP-CB-2014-01-242443).
Editor
SPRINGER Netherlands
Fecha de publicación
8 de septiembre de 2017
Tipo de publicación
Artículo
Recurso de información
Fuente
1588-2780
0236-5731
Idioma
Inglés
Relación
doi;10.1007/s10967-017-5465-x
Audiencia
Estudiantes
Investigadores
Repositorio Orígen
REPOSITORIO INSTITUCIONAL DE LA UAEM
Descargas
269