Título

Acrylamide acute neurotoxicity in adult zebrafish

Autor

Melissa Faria

Tamar Ziv

Cristian Gómez-Canela

SHANI BEN LULU

Eva Prats

KAREN ADRIANA NOVOA LUNA

Arie Admon

Benjamin Piña

Roma Tauler

Leobardo Manuel Gómez Olivan

Demetrio Raldua

Nivel de Acceso

Acceso Abierto

Licencia

http://creativecommons.org/licenses/by-nc-nd/4.0

Materias

acrylamide - ([2045-2322]) zebra fish - ([2045-2322]) behavior - ([2045-2322]) BIOLOGÍA Y QUÍMICA - (CTI)

Resumen o descripción

Un articulo indexado

Acute exposure to acrylamide (ACR), a type-2 alkene, may lead to a ataxia, skeletal muscles weakness and numbness of the extremities in human and laboratory animals. In the present manuscript, ACR acute neurotoxicity has been characterized in adult zebrafish, a vertebrate model increasingly used in human neuropharmacology and toxicology research. At behavioral level, ACR-treated animals exhibited “depression-like” phenotype comorbid with anxiety behavior. At transcriptional level, ACR induced down-regulation of regeneration-associated genes and up-regulation of oligodendrocytes and reactive astrocytes markers, altering also the expression of genes involved in the presynaptic vesicle cycling. ACR induced also significant changes in zebrafish brain proteome and formed adducts with selected cysteine residues of specific proteins, some of them essential for the presynaptic function. Finally, the metabolomics analysis shows a depletion in the monoamine neurotransmitters, consistent with the comorbid depression and anxiety disorder, in the brain of the exposed fish.

Conacyt

Editor

Scientific REPORTs

Fecha de publicación

21 de mayo de 2018

Tipo de publicación

Artículo

Recurso de información

http://hdl.handle.net/20.500.11799/94975

Fuente

2045-2322

Idioma

Inglés

Audiencia

Estudiantes

Investigadores

Repositorio Orígen

REPOSITORIO INSTITUCIONAL DE LA UAEM

Descargas

498