Título

High relative abundance of firmicutes and increased TNF- ¿ levels correlate with obesity in children.

Autor

YANETH CITLALLI ORBE ORIHUELA

ALFREDO LAGUNAS MARTINEZ

MARGARITA BAHENA ROMAN

Vicente Madrid Marina

KIRVIS JANNETH TORRES POVEDA

EUGENIA FLORES ALFARO

CINTHYA ESTEFHANY DIAZ BENITEZ

OSCAR PERALTA ZARAGOZA

ANA ISABEL BURGUETE GARCIA

Nivel de Acceso

Acceso Abierto

Resumen o descripción

To investigate the correlation among pro- or anti-inflammatory cytokines and the two main gut microbiota phyla in obese children. Materials and methods. Anthropometric data were obtained from 890 children under 14 years old to determine the degree of obesity. Serum cytokine concentration was measured by ELISA. Relative abundance of gut microbiota in feces was evaluated by quantitative Real-Time PCR assays. Results. Anthropometric and biochemical parameters were statistically higher in overweight /obese children than in lean ones. Increased TNF-¿ levels were found in obese children that also have a high relative abundance of Firmicutes. Conclusions. Obese children have a high relative abundance of Firmicutes that correlates with increased levels of TNF-¿. This is the first study that shows a relation between Firmicute abundance and TNF-¿ serum concentration in obese children.

Editor

Salud Pública de México

Fecha de publicación

24 de febrero de 2017

Tipo de publicación

Artículo

Recurso de información

Formato

application/pdf

Idioma

Español

Audiencia

Público en general

Repositorio Orígen

Repositorio Institucional de Ciencia Abierta de la Universidad Autónoma de Guerrero

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