Título

Differential proteins among normal cérvix cells and cervical cancer cells with HPV-16 infection, through mass spectrometrybased Proteomics (2D-DIGE) in women from Southern México

Autor

Idanya Rubí Serafín Higuera

Olga Lilia Garibay Cerdenares

Berenice Illades_Aguiar

Eugenia Flores Alfaro

Marco Antonio Jiménez López

Pavel Sierra Martínez

Luz Del Carmen Alarcón Romero

Nivel de Acceso

Acceso Abierto

Resumen o descripción

We thank the strengthening program graduate high with file number: I010/455/2013 C- 677/2013 of UAGro. Serafín-Higuera I was recipient of a Doctoral fellowship with file number 222252 from CONACYT, México.

Cervical cancer (CC) is the fourth most common cancer in women worldwide with an estimated 528,000 new cases in 2012. The same year México had an incidence of 13,960 and a mortality of 4769 cases. There are several diagnosis methods of CC; among the most frequents are the conventional Pap cytology (Pap), colposcopy, and visual inspection with acetic acid (VIA), histopathological examination, tests of imaging and detection of high-risk papilloma virus (HR-HPV) with molecular tests (PCR, hybridization, sequencing). Proteomics is a tool for the detection of new biomarkers that can be associated with clinical stage, histological type, prognosis, and/or response to treatment. In this study we performed a comparative analysis of CC cells with normal cervical cells. The proteomic analysis was carried out with the fluorescent two-dimensional electrophoresis (2D-DIGE) technique to subsequently identify differential protein profiles using Decyder Software, and the selected proteins were identified by Mass Spectrometry (MALDI-TOF).

Editor

Proteome Science

Fecha de publicación

5 de septiembre de 2016

Tipo de publicación

Artículo

Recurso de información

Formato

application/pdf

Idioma

Inglés

Audiencia

Público en general

Repositorio Orígen

Repositorio Institucional de Ciencia Abierta de la Universidad Autónoma de Guerrero

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