Título
Differential proteins among normal cérvix cells and cervical cancer cells with HPV-16 infection, through mass spectrometrybased Proteomics (2D-DIGE) in women from Southern México
Autor
Idanya Rubí Serafín Higuera
Olga Lilia Garibay Cerdenares
Berenice Illades_Aguiar
Eugenia Flores Alfaro
Marco Antonio Jiménez López
Pavel Sierra Martínez
Luz Del Carmen Alarcón Romero
Nivel de Acceso
Acceso Abierto
Materias
Resumen o descripción
We thank the strengthening program graduate high with file number: I010/455/2013 C- 677/2013 of UAGro. Serafín-Higuera I was recipient of a Doctoral fellowship with file number 222252 from CONACYT, México.
Cervical cancer (CC) is the fourth most common cancer in women worldwide with an estimated 528,000 new cases in 2012. The same year México had an incidence of 13,960 and a mortality of 4769 cases. There are several diagnosis methods of CC; among the most frequents are the conventional Pap cytology (Pap), colposcopy, and visual inspection with acetic acid (VIA), histopathological examination, tests of imaging and detection of high-risk papilloma virus (HR-HPV) with molecular tests (PCR, hybridization, sequencing). Proteomics is a tool for the detection of new biomarkers that can be associated with clinical stage, histological type, prognosis, and/or response to treatment. In this study we performed a comparative analysis of CC cells with normal cervical cells. The proteomic analysis was carried out with the fluorescent two-dimensional electrophoresis (2D-DIGE) technique to subsequently identify differential protein profiles using Decyder Software, and the selected proteins were identified by Mass Spectrometry (MALDI-TOF).
Editor
Proteome Science
Fecha de publicación
5 de septiembre de 2016
Tipo de publicación
Artículo
Recurso de información
Formato
application/pdf
Idioma
Inglés
Audiencia
Público en general
Repositorio Orígen
Repositorio Institucional de Ciencia Abierta de la Universidad Autónoma de Guerrero
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