Título

DNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation

Autor

Irlanda Peralta Arrieta

Daniel Hernández Sotelo

Yaneth Castro Coronel

Marco Antonio Leyva Vázquez

Berenice Illades Aguiar

Nivel de Acceso

Acceso Abierto

Licencia

http://creativecommons.org/licenses/by-nc-nd/4.0

Materias

Methylation De novo methyltransferase Overexpression of DNMT3B Cancer Cancer-related genes CpG island MEDICINA Y CIENCIAS DE LA SALUD - (CTI) CIENCIAS MÉDICAS - (CTI) PATOLOGÍA - (CTI) CARCINOGÉNESIS - (CTI)

Resumen o descripción

Altered promoter DNA methylation is one of the most important epigenetic abnormalities in human cancer. DNMT3B, de novo methyltransferase, is clearly related to abnormal methylation of tumour suppressor genes, DNA repair genes and its overexpression contributes to oncogenic processes and tumorigenesis in vivo. The purpose of this study was to assess the effect of the overexpression of DNMT3B in HaCaT cells on global gene expression and on the methylation of selected genes to the identification of genes that can be target of DNMT3B. We found that the overexpression of DNMT3B in HaCaT cells, modulate the expression of genes related to cancer, downregulated the expression of 151 genes with CpG islands and downregulated the expression of the VAV3 gene via methylation of its promoter. These results highlight the importance of DNMT3B in gene expression and human cancer

Editor

American Journal of Cancer Research

Fecha de publicación

2017

Tipo de publicación

Artículo

Recurso de información

http://ri.uagro.mx/handle/uagro/405

Formato

application/pdf

Idioma

Inglés

Audiencia

Público en general

Repositorio Orígen

Repositorio Institucional de Ciencia Abierta de la Universidad Autónoma de Guerrero

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