Título
Immune Response Induced by an Immunodominant 60 kDa Glycoprotein of the Cell Wall of Sporothrix schenckii in Two Mice Strains with Experimental Sporotrichosis.
Autor
Carlos Antonio Alba Fierro
Armando Perez Torres
Concepcion Toriello Najera
Evelyn Pulido Camarillo
Everardo Lopez Romero
Yolanda Romo Lozano
Gerardo Gutierrez Sanchez
Estela Ruiz Baca
Nivel de Acceso
Acceso Abierto
Identificador alterno
doi: 10.1155/2016/6525831
Materias
Micología - ([Journal of Immunology Research (2314-7156) 1-15 (2016)]) Sporothrix schenckii - ([Journal of Immunology Research (2314-7156) 1-15 (2016)]) Respuesta inmune - ([Journal of Immunology Research (2314-7156) 1-15 (2016)]) Esporotricosis - ([Journal of Immunology Research (2314-7156) 1-15 (2016)]) Lesiones en piel - ([Journal of Immunology Research (2314-7156) 1-15 (2016)]) BIOLOGÍA Y QUÍMICA - (CTI)
Resumen o descripción
Cell wall (CW) components of fungus Sporothrix schenckii are the major inductors antigens of immune response. The immunodominant 60 kDa glycoprotein (gp60) has been shown to be associated with the virulence of this fungus but its role in experimental sporotrichosis is unknown. In this work, the immunological effects of CW-purified gp60 were investigated in a model of experimental subcutaneous sporotrichosis in normal and gp60-preimmunized C57BL/6 and BALB/c mice strains which were then infected with S. schenckii conidia. Results showed that both mice strains use different cytokine profiles in order to fight S. schenckii infection; C57BL/6 mice seem to use a Th17 response while BALB/c mice tend to depend on a Th1 profile. Preimmunization with gp60 showed a downregulatory effect on the immune response since cytokines levels were diminished in both strains. There were no significant differences in the magnitude of dorsoplantar inflammation between gp60-preimmunized and nonimmunized mice of both strains. However, skin lesions due to the infection in gp60-preimmunized mice were more severe in BALB/c than in C57BL/6 mice, suggesting that the antigen exerts a higher downregulatory effect on the Th1 response.
Editor
Hindawi
Fecha de publicación
2016
Tipo de publicación
Artículo
Versión de la publicación
Versión publicada
Recurso de información
Formato
application/pdf
Fuente
Journal of Immunology Research (2314-7156) 1-15 (2016)
Idioma
Inglés
Relación
https://www.hindawi.com/journals/jir/contents/35/
Cobertura
EG
Repositorio Orígen
Repositorio Institucional de la Facultad de Medicina,UNAM.Departamento de Microbiologia y Parasitologia
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