Título
Clustering of Mycobacterium tuberculosis Cases in Acapulco: Spoligotyping and Risk Factors.
Autor
Elizabeth Nava Aguilera
Yolanda Lopez Vidal
Eva Harris
Arcadio Morales Perez
Steven Mitchell
Miguel Flores Moreno
Ascencio Villegas Arrizon
Jose Legorreta Soberanis
Robert Ledogar
Neil Andersson
Nivel de Acceso
Acceso Abierto
Identificador alterno
doi: http://dx.doi.org/10.1155/2011/408375
Materias
Bacteriología - ([Clinical and Developmental Immunology (2314-6141), 1-12 (2011)]) Mycobacterium tuberculosis - ([Clinical and Developmental Immunology (2314-6141), 1-12 (2011)]) Epidemiología - ([Clinical and Developmental Immunology (2314-6141), 1-12 (2011)]) MEDICINA Y CIENCIAS DE LA SALUD - (CTI)
Resumen o descripción
Recurrence and reinfection of tuberculosis have quite different implications for prevention. We identified 267 spoligotypes of Mycobacterium tuberculosis from consecutive tuberculosis patients in Acapulco, Mexico, to assess the level of clustering and risk factors for clustered strains. Point cluster analysis examined spatial clustering. Risk analysis relied on the Mantel Haenszel procedure to examine bivariate associations, then to develop risk profiles of combinations of risk factors. Supplementary analysis of the spoligotyping data used SpolTools. Spoligotyping identified 85 types, 50 of them previously unreported. The five most common spoligotypes accounted for 55% of tuberculosis cases. One cluster of 70 patients (26% of the series) produced a single spoligotype from the Manila Family (Clade EAI2). The high proportion (78%) of patients infected with cluster strains is compatible with recent transmission of TB in Acapulco. Geomatic analysis showed no spatial clustering; clustering was associated with a risk profile of uneducated cases who lived in single-room dwellings. The Manila emerging strain accounted for one in every four cases, confirming that one strain can predominate in a hyperendemic area.
Editor
Hindawi
Fecha de publicación
2011
Tipo de publicación
Artículo
Versión de la publicación
Versión publicada
Recurso de información
Formato
application/pdf
Fuente
Clinical and Developmental Immunology (2314-6141), 1-12 (2011)
Idioma
Inglés
Relación
https://www.hindawi.com/journals/jir/contents/
Cobertura
EG
Repositorio Orígen
Repositorio Institucional de la Facultad de Medicina,UNAM.Departamento de Microbiologia y Parasitologia
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