Author: Hector Alejandro Cabrera Fuentes
Ischemic heart disease (IHD) is one of the leading causes of death and disability worldwide. Platelets, as the main regulators of hemostasis, are major players in acute myocardial ischemia/reperfusion injury (IRI). Additionally, platelets are modified by endogenous cardioprotective strategies such as ischemic preconditioning, postconditioning, and remote ischemic conditioning. In this article, we provide an overview of the functionional role of platelets in acute myocardial IRI, and highlight their potential as targets for cardioprotection to improve health outcomes in patients with IHD.
Hector Alejandro Cabrera Fuentes Corina Mariela Alba Alba Julian Aragones Lopez Jürgen Bernhagen WilliamBoisvert Hans Erik Bøtker Gabriela Nora Cesarman Maus Ingrid Fleming David García-Dorado García Sandrine Lecour Elisa A. Liehn Michael Marber Nephtali Marina Gonzalez Manuel Mayr Oscar Armando Perez Mendez Tetsuji Miura Marisol Ruiz Meana Eduardo Marcos Salinas Stefanon Sang-Bing Ong Hans-J. Schnittler Trinidad Sánchez Vega Adriana Sumoza Toledo Carl Vogel Dina Yarullina Derek Yellon Klaus T. Nielsen Derek Hausenloy (2016)
Recent advances in basic cardiovascular research as well as their translation into the clinical situation were the focus at the last "New Frontiers in Cardiovascular Research meeting". Major topics included the characterization of new targets and procedures in cardioprotection, deciphering new players and inflammatory mechanisms in ischemic heart disease as well as uncovering microRNAs and other biomarkers as versatile and possibly causal factors in cardiovascular pathogenesis. Although a number of pathological situations such as ischemia-reperfusion injury or atherosclerosis can be simulated and manipulated in diverse animal models, also to challenge new drugs for intervention, patient studies are the ultimate litmus test to obtain unequivocal information about the validity of biomedical concepts and their application in the clinics. Thus, the open and bidirectional exchange between bench and bedside is crucial to advance the field of ischemic heart disease with a particular emphasis of understanding long-lasting approaches in cardioprotection.
Ateroesclerosis Cardioprotección Enfermedad cardiovascular Permeabilidad endotelial RNA extracelular Lipoproteína de alta densidad Hipoxia Inflamación Isquemia Lesión por reperfusión Polarización de macrófagos MicroRNAs Mitocondria Disfunción plaquetaria Biología vascular MEDICINA Y CIENCIAS DE LA SALUD