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Efecto del CdCl2 sobre la expresión de DNA metiltransferasas y la metilación de los genes RASSF1A, MGMT y SOX17 en células HepG2

Sonia Ivette Alcocer Lorenzo (2019)

Consejo Nacional de Ciencia y Tecnología (CONACYT)

Cadmium (Cd) is a highly toxic heavy metal, established as carcinogen. There is evidence of Cd mediated epigenetic modifications, such as changes in methylation, resulting in alteration in target gene expression. This could be attributed to changes in the expression of DNA methyltransferases (DNMTs), enzymes responsible for methylation.

Master thesis

Cadmium Acido desoxirribonucleico Methyltransferase BIOLOGÍA Y QUÍMICA QUÍMICA

DNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation

Irlanda Peralta Arrieta Daniel Hernández Sotelo Yaneth Castro Coronel Marco Antonio Leyva Vázquez Berenice Illades Aguiar (2017)

Altered promoter DNA methylation is one of the most important epigenetic abnormalities in human cancer. DNMT3B, de novo methyltransferase, is clearly related to abnormal methylation of tumour suppressor genes, DNA repair genes and its overexpression contributes to oncogenic processes and tumorigenesis in vivo. The purpose of this study was to assess the effect of the overexpression of DNMT3B in HaCaT cells on global gene expression and on the methylation of selected genes to the identification of genes that can be target of DNMT3B. We found that the overexpression of DNMT3B in HaCaT cells, modulate the expression of genes related to cancer, downregulated the expression of 151 genes with CpG islands and downregulated the expression of the VAV3 gene via methylation of its promoter. These results highlight the importance of DNMT3B in gene expression and human cancer


Methylation De novo methyltransferase Overexpression of DNMT3B Cancer Cancer-related genes CpG island MEDICINA Y CIENCIAS DE LA SALUD CIENCIAS MÉDICAS PATOLOGÍA CARCINOGÉNESIS