Systematic Literature Review on Smart Specialization: Future Prospects and Opportunities

Beatriz Rosas Michael Demmler (2023, [Artículo])

"Smart specialisation (SS) has been the new cohesion policy in the European Union during the last two periods. The present study aims to analyse the most relevant existing state-of-the-art literature on smart specialisation through a systematic and bibliometric review. Using the Web of Science bibliographic database, we analysed the content of 207 articles under the TCCM methodology and constructed a network of citations in order to summarize theories, characteristics, context and methods presented in existing studies on the topic. Our results show the theoretical and methodological gaps of the past, such as Entrepreneurial Discovery Process and SS indicators. These remain to the present day. The context analysis showed that the scope of smart specialisation extended beyond the frontiers of the European Union, given how it has been adopted by other countries as well. These results suggest the importance of developing a more robust theoretical, conceptual and methodological framework. Consequently, the guides need to be more accurate and should be continuously updated. Our results are valuable for the EDP actors and have policymaking implications".

Especialización inteligente Estrategias de innovación regional Revisión de literatura sistemática Métodos de especialización inteligente Smart specialization Smart specialization methods CIENCIAS SOCIALES CIENCIAS SOCIALES

Chapter 11. Genomic insights on global journeys of adaptive wheat genes that brought us to modern wheat

deepmala sehgal Laura Dixon Diego Pequeno Jose Crossa Alison Bentley Susanne Dreisigacker (2024, [Capítulo de libro])

Hexaploid Wheat Adaptive Genes Novel Genomic Regions Gene-Based Modeling Process-Based Modeling Global Food Security CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA HEXAPLOIDY WHEAT QUANTITATIVE TRAIT LOCI MODELLING FOOD SECURITY

Mujeres y nación. Discursos sobre identidades de género e identidades nacionales en la prensa femenina chilena de comienzos del siglo XX

Valeria Alejandra Olivares Olivares (2016, [Tesis de maestría])

Instituto de Investigaciones Históricas. Facultad de Historia. Programa Institucional de Maestría en Historia

In this text, the reader will find a study about public participation of women in the national discussion context, that occurred in the first two decades of the twentieth century in Chile. To get the objective we have chosen two hemerography sources self-styled "women's magazines": the workers paper La Alborada (1905-1907) and the publication of elite La Revista Azul (1914-1918), to approach the discources doomed to 'question feminine', construction of gender identities and processes of significance of women in the framework of the named readjusted of national identities, as a cultural practice. The text has been divided in three chapters. The first look for the study of the relationships found in the 'official'. The second chapter is about the female press production and identity marks that defined the public women affairs. Finally, the third chapter will focus on the discursive representations found in these two cases, by three analytical categories that allow us to understand the mechanisms of participation of women in the nation: instruction, moralizing and motherhood.

En el presente texto, el lector podrá encontrar un estudio sobre la participación pública de las mujeres en el marco de la discusión sobre 'lo nacional', acaecido en las primeras dos décadas del siglo XX en Chile . Para esto, se han escogido dos fuentes hemerográficas autodenominadas como "prensa femenina": el periódico obrero La Alborada (1905-1907) y la publicación de élite La Revista Azul (1914-1918), con el objetivo de abordar los discursos abocados a la 'cuestión femenina', la construcción de identidades de género y los procesos de significación de las mujeres en el marco de la denominada readecuación de las identidades nacionales, todo esto, como una práctica cultural. Así, el texto ha sido estructurado en tres capítulos. El primero busca revisar el contexto de estudio y las relaciones establecidas entre los discursos analizados con el 'oficial'. El segundo capítulo está orientado a la producción de la prensa femenina y las marcas identitarias que definieron el quehacer público de las mujeres. Finalmente, el tercer capítulo se abocará a las representaciones discursivas encontradas en estos dos casos, por medio de tres categorías analíticas que permiten comprender los mecanismos de participación de las mujeres en la nación: la instrucción, la moralización y la maternidad.

HUMANIDADES Y CIENCIAS DE LA CONDUCTA FH-M-2016-0343 Opción en historia regional continental Identidades de género Identidades nacionales Prensa femenina Chile

Synthetic libraries of shark vNAR domains with different cysteine numbers within the CDR3

OLIVIA CABANILLAS BERNAL (2019, [Artículo])

The variable domain of New Antigen Receptors (vNAR) from sharks, present special characteristics in comparison to the conventional antibody molecules such as: small size (12–15 kDa), thermal and chemical stability and great tissue penetration, that makes them a good alternative source as therapeutic or diagnostic agents. Therefore, it is essential to improve techniques used for the development and selection of vNAR antibodies that recognize distinct antigens. The development of synthetic antibody libraries offers a fast option for the generation of antibodies with the desired characteristics. In this work three synthetic antibody libraries were constructed; without cysteines (Cys), with one Cys and with two Cys residues within its CDR3, with the objective of determining whether the presence or absence of Cys in the CDR3 favors the isolation of vNAR clones from a synthetic library. The libraries were validated selecting against six mammalian proteins. At least one vNAR was found for each of the antigens, and a clone coming from the library without Cys in the CDR3 was selected with all the antigens. In vitro angiogenesis assay with the isolated anti-VEGF antibodies, suggest that these vNARs are capable of inhibiting in vitro angiogenesis. In silico analysis of anti-VEGF antibodies showed that vNARs from synthetic libraries could rival antibodies with affinity maturation by in silico modeling. © 2019 Cabanillas-Bernal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

aquaporin 1, carcinoembryonic antigen, cysteine, fibroblast growth factor 2, glycophorin A, leukemia inhibitory factor, vasculotropin, vasculotropin antibody, angiogenesis inhibitor, antibody, cysteine, lymphocyte antigen receptor, vasculotropin A, a BIOLOGÍA Y QUÍMICA CIENCIAS DE LA VIDA BIOFÍSICA BIOFÍSICA

A new species of Encelia (Compositae, Heliantheae, Enceliinae) from the southern Baja California Peninsula

JOSE LUIS LEON DE LA LUZ Isaac Lichter-Marck (2022, [Artículo])

"Se ilustra y describe a una nueva especie de Asteraceae, Encelia balandra. Se conoce solo de las laderas rocosas de los cerros próximos a puerto Balandra y Pichilingue, dentro de la bahía de La Paz, en Baja California Sur, México. Encontramos que esta nueva especie tiene ciertas semejanzas con otras de Encelia por su hábito semiarbustivo, las flores radiales neutras y cipselas comprimidas con ápice hendido. Confirmamos tal condición con datos de secuencia para las regiones ITS y ETS del genoma. También presentamos fotografías detalladas, un evaluación de conservación, y un clave dichotomus para los Encelia de Baja California sur. Se discute la semejanza con las especies peninsulares más cercanas de Encelia, se presenta una clave dicotómica para los taxonesaustrales de la península de Baja California, y finalmente se muestran imágenes detalladas de esta nueva especie."

"Here, we describe and illustrate Encelia balandra sp. nov., a new species of Compositae from the Baja Cal- ifornia Peninsula. It is rare and known only from the rocky hills around Puerto Balandra and Pichilingüe, inside the bay of La Paz, in the State of Baja California Sur, Mexico. We determine that this new species has affinities with Encelia, based on its suffruticose woody habit, neuter ray florets and compressed disc cypselae with a cleft apex. The taxonomic placement within Encelia is supported by nuclear ribosomal sequence data from two regions, ITS and ETS. We also present detailed photographs, a conservation assessment and a dichotomous key to the Encelia of the southern Baja California Peninsula. Finally, we discuss the uniqueness of Encelia balandra amongst peninsular Encelia and its potential significance for understanding the enigmatic biogeography of this ecologically important genus."

Asteraceae, Cape region, DNA barcoding, narrow endemism, synantherology, taxonomy Código de barras ADN, Micro-endemismo, Región de Los Cabos, Sinanterología, Taxonomía BIOLOGÍA Y QUÍMICA CIENCIAS DE LA VIDA BIOLOGÍA VEGETAL (BOTÁNICA) ECOLOGÍA VEGETAL ECOLOGÍA VEGETAL

Dormitator latifrons (Richardson, 1844) a Pacific fat sleeper, but skinny in research: a scientometric study

MARTIN ALONSO ARECHIGA PALOMERA KAREN NOEMI NIEVES RODRIGUEZ OLIMPIA CHONG CARRILLO Héctor Gerardo Nolasco Soria Emyr Saúl Peña Marín Carlos Alfonso Alvarez_González DAVID JULIAN PALMA CANCINO RAFAEL MARTINEZ GARCIA DANIEL BADILLO ZAPATA FERNANDO VEGA VILLASANTE (2022, [Artículo])

"In order to provide information on the current knowledge about the native fish Dormitator latifrons and identify the gaps that must be filled to achieve correct resource management, a scientometric study was carried out using different scientific databases. A total of 103 publications were registered between the years 1972 and 2021. Results indicate that the species has been addressed since 2001 with less than one publication per year, with 2008 being the year with the highest number of publications (10). The main topics addressed were ecology, physiology, and parasitology of fish. The available knowledge generated about the species is concentrated in 68 journals, with Mexico as the most productive country, followed by USA and Ecuador, and the most productive research centers about this fish were Mexico’s Instituto Politécnico Nacional and Universidad de Guadalajara. A total of 285 authors were detected contributing knowledge to the species, with Violante-González in the top with ten publications. The co-authorship co-occurrence maps suggest there is no solid collaborative relationship between the scientific community and that the information generated is insufficient for conserving and exploiting this fish. It is essential to increase the study of thematic areas that allow their comprehensive management in the medium term; topics like reproduction in captivity, aquaculture, and nutrition must be addressed in the future to assure a sustainable use of this resource."

Dormitator latifrons, native fish, amphidromous, worldwide database, regional database, cooccurrence map CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA CIENCIAS AGRARIAS PECES Y FAUNA SILVESTRE DINÁMICA DE LAS POBLACIONES DINÁMICA DE LAS POBLACIONES

Low thermal conductivity solar domestic water heater

MIGUEL ANGEL PORTA GANDARA JOSE LUIS FERNANDEZ ZAYAS JUAN FRANCISCO VILLA MEDINA NORBERTO CHARGOY DEL VALLE (2022, [Artículo])

"Solar domestic water heaters (SWH) with thermosyphon circulation are the most common commercial applications of solar energy in Mexico. They are also becoming popular in the rest of the world, given their simplicity, good economic returns, and sustainability. Traditionally the solar collector, the piping, and the storage tank are built of copper and steel. However, wáter quality in many parts of the Mexican Northwest has high mineral contents and, when heated, results in early metal pitting corrosion of SWH parts. Short-lived water heaters are bad promoters of the technology. In this work, a SWH thermoplastic Chlorinated Polyvinyl Chloride (CPVC) is built and tested under real operating conditions in La Paz, BCS, Mexico. The optimal design is detected with the aid of a suitable numerical model. Results reveal that a full SWH-CPVC can be technically and economically convenient for the weather conditions of the Northwestern states of Mexico."

Low thermal conductivity solar water heater CPVC solar water heater Solar water heater cooper pitting corrosion Thermosiphon circulation INGENIERÍA Y TECNOLOGÍA CIENCIAS TECNOLÓGICAS TECNOLOGÍA ELECTRÓNICA DISPOSITIVOS TERMOELÉCTRICOS DISPOSITIVOS TERMOELÉCTRICOS

Sustainability assessment based on stakeholders’ perception of tourism activities in Loreto Bay National Park, Mexico

Evaluación de la sustentabilidad basada en la percepción de las partes interesadas sobre las actividades turísticas en el Parque Nacional Bahía de Loreto, México

Iris Aurora del Castillo Velasco Martínez Luis Felipe Beltrán Morales Alfredo Ortega Rubio GUSTAVO ALBERTO ARNAUD FRANCO GERZAIN AVILES POLANCO Angel Herrera (2022, [Artículo])

"To assess the level of sustainability, based on stakeholders’ tourism perceptions of Loreto Bay National Park (LBNP) in Mexico. Methodology: Indicators were selected and organized in three components: (1) destination management; (2) social, economic, and cultural impact; (3) environmental impact; and two dimensions: social and environmental. Surveys were applied to tourist companies, residents, and visitors. Contingency tables were used to identify significant dependence between indicators. Results: The results showed an acceptable sustainability level. Indicators with lower value were residents’ knowledge about PA, the benefit they obtain from tourism, as well as their participation in environmental activities. Limitations: Some of the indicators used are specific to LBNP, therefore they should be adequate for each PA. Conclusions: The study concludes with the contributions of the method and a series of recommendations to increases residents’ economic benefit and their involvement in PA management."

"Valuar el nivel de sustentabilidad, con base en las percepciones turísticas de las partes interesadas del Parque Nacional Bahía de Loreto (PNLB) en México. Metodología: se seleccionaron indicadores y se organizaron en tres componentes: (1) gestión de destinos; (2) impacto social, económico y cultural; (3) impacto ambiental; y dos dimensiones: social y ambiental. Se aplicaron encuestas a empresas turísticas, residentes y visitantes. Se utilizaron tablas de contingencia para identificar la dependencia significativa entre indicadores. Resultados: un nivel de sustentabilidad aceptable. Los indicadores con menor valor fueron el conocimiento de los residentes sobre las AP, el beneficio que obtienen del turismo, así como su participación en actividades ambientales. Limitaciones: algunos de los indicadores empleados son específicos para el PNBL, por lo que deben adecuarse a cada AP. Conclusiones: las aportaciones del método y una serie de recomendaciones para incrementar el beneficio económico de los residentes y su participación en la gestión de las AP."

regional development, indicator, national park, perception, protected area, stakeholders, sustainability, tourism desarrollo regional, indicador, parque nacional, percepción, área protegida, stakeholders, sustentabilidad, turismo CIENCIAS SOCIALES CIENCIAS ECONÓMICAS ECONOMÍA SECTORIAL ECONOMÍA SECTORIAL. TURISMO ECONOMÍA SECTORIAL. TURISMO

Suppression of breast tumor growth and metastasis by an engineered transcription factor

Adriana Beltran Lopez (2011, [Artículo])

Maspin is a tumor and metastasis suppressor playing an essential role as gatekeeper of tumor progression. It is highly expressed in epithelial cells but is silenced in the onset of metastatic disease by epigenetic mechanisms. Reprogramming of Maspin epigenetic silencing offers a therapeutic potential to lock metastatic progression. Herein we have investigated the ability of the Artificial Transcription Factor 126 (ATF-126) designed to upregulate the Maspin promoter to inhibit tumor progression in pre-established breast tumors in immunodeficient mice. ATF-126 was transduced in the aggressive, mesenchymal-like and triple negative breast cancer line, MDA-MB-231. Induction of ATF expression in vivo by Doxycycline resulted in 50% reduction in tumor growth and totally abolished tumor cell colonization. Genome-wide transcriptional profiles of ATF-induced cells revealed a gene signature that was found over-represented in estrogen receptor positive (ER+) "Normal-like" intrinsic subtype of breast cancer and in poorly aggressive, ER+ luminal A breast cancer cell lines. The comparison transcriptional profiles of ATF-126 and Maspin cDNA defined an overlapping 19-gene signature, comprising novel targets downstream the Maspin signaling cascade. Our data suggest that Maspin up-regulates downstream tumor and metastasis suppressor genes that are silenced in breast cancers, and are normally expressed in the neural system, including CARNS1, SLC8A2 and DACT3. In addition, ATF-126 and Maspin cDNA induction led to the re-activation of tumor suppressive miRNAs also expressed in neural cells, such as miR-1 and miR-34, and to the down-regulation of potential oncogenic miRNAs, such as miR-10b, miR-124, and miR-363. As expected from its over-representation in ER+ tumors, the ATF-126-gene signature predicted favorable prognosis for breast cancer patients. Our results describe for the first time an ATF able to reduce tumor growth and metastatic colonization by epigenetic reactivation of a dormant, normal-like, and more differentiated gene program. © 2011 Beltran et al.

artificial transcription factor 126, complementary DNA, doxycycline, estrogen receptor, maspin, microRNA, retrovirus vector, transcription factor, unclassified drug, estrogen receptor, serine proteinase inhibitor, SERPIN B5, SERPIN-B5, transcription BIOLOGÍA Y QUÍMICA CIENCIAS DE LA VIDA BIOLOGÍA ANIMAL (ZOOLOGÍA) BIOLOGÍA ANIMAL (ZOOLOGÍA)

Expansión poblacional reciente en la historia evolutiva de la anchoveta de California Engraulis mordax

Recent population expansion in the evolutionary history of the Californian anchovy Engraulis mordax

NOE DIAZ VILORIA LAURA SANCHEZ VELASCO RICARDO PEREZ ENRIQUEZ (2012, [Artículo])

"La anchoveta de California Engraulis mordax, es una especie templada que pudo haber pasado por un proceso de disyunción poblacional, debido al proceso postglacial de calentamiento del agua alrededor de la punta de la península de Baja California, hace unos 10,000 años. Se realizó un análisis genético para probar la hipótesis nula de homogeneidad genética entre el Golfo de California, México y el sur de California, EUA y si este era el caso, estimar el tiempo de surgimiento de haplotipos en términos de coalescencia. Se analizaron en total 80 secuencias de la región control hipervariable (ADNmt) de E. mordax, capturadas en la región central del Golfo de California (n = 40) y el sur de California (n = 40). A pesar del gran número de haplotipos únicos, no se observó diferenciación genética significativa entre localidades (FST = –0.0025, p = 0.686). Una distribución unimodal en la frecuencia del número de diferencias entre haplotipos indica un modelo de expansión rápida en el tamaño poblacional, que basado en una tasa mutacional de 3.6% por millón de años para la región control, indicó un tiempo de diferenciación nucleotídica relativamente reciente de aproximadamente 61,000 años. Este periodo de tiempo corresponde al Pleistoceno tardío, después de la formación de la península de Baja California, sugiriendo expansiones poblacionales en cada una de las localidades, seguidas del último episodio de glaciación, el cual quizás contribuyó a la migración de esta especie de afinidad templada entre las dos localidades y a su homogenización genética. Sin embargo este único evento reciente de flujo genético en la historia evolutiva de la especie, no explica por sí solo los patrones de distribución encontrados en las frecuencias de diferencias nucleotídicas."

"The Californian anchovy Engraulis mordax, a temperate species, may have undergone a process of population disjunction from experiencing post-glacial water heating processes around the tip of the Baja California Peninsula, Mexico about 10,000 b.p. A genetic analysis was performed to test the null hypothesis of genetic homogeneity between the Gulf of California and Southern California, U. S. A., and if this is the case, to estimate the time of haplotype emergence in terms of coalescence. A total of 80 sequences of the mtDNA hypervariable control region of E. mordax captured in the central Gulf of California (n = 40) and Southern California (n = 40) were analyzed. In spite of the large number of private haplotypes, no significant genetic differentiation among sites (FST = –0.0025, p = 0.686) was observed. An unimodal distribution of mismatch frequency between haplotypes indicated a model of rapid expansion in population size that, based on a mutation rate of 3.6% per million years in the control region, indicates a relatively recent nucleotide differentiation

time of approximately 61,000 years. This time period corresponds to the late Pleistocene, suggesting population expansions at each locality, followed by the last episode of glaciation, which may have contributed to migration of this temperate-affinity species between two locations and the genetic homogenization. However this unique recent event of gene flow in the evolutionary history of species does not explain by itself the mismatch distribution patterns found."

ADN mitocondrial, expansión poblacional reciente, flujo genético, región control, reloj molecular. Control region, gene flow, mitochondrial DNA, molecular clock, recent population expansion. BIOLOGÍA Y QUÍMICA CIENCIAS DE LA VIDA BIOLOGÍA ANIMAL (ZOOLOGÍA) ZOOLOGÍA MARINA ZOOLOGÍA MARINA