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Selecciona los temas de tu interés y recibe en tu correo las publicaciones más actuales
Abdelfattah DABABAT Yong Suk Chung (2023, [Artículo])
Biological Indexing Sequencing Analysis Citrus Orchards CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA PHYLOGENETIC ANALYSIS CITRUS RNA DNA
Yong Zhang Leonardo Abdiel Crespo Herrera Julian Chen (2022, [Artículo])
Cereal Aphid Salivary Protein Plant Immunity RNA Interference Aphid Performance CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA APHIDOIDEA PLANTS RNA PROTEINS
Shailendra Sharma deepmala sehgal Apekshita Singh Shailendra Goel SoomNath Raina (2022, [Artículo])
Corona Viruses Genome Structure Novel Mutations Resistance to Vaccines SARS-CoV-2 CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA COVID-19 ANTIBODY FORMATION LIFE CYCLE VACCINATION VACCINES LINEAGE
Jode Edwards Sarah Hearne (2023, [Artículo])
Homozygous Lines CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA GENETIC DIVERSITY (AS RESOURCE) GENETIC RESOURCES ZEA MAYS GENOTYPING DOUBLED HAPLOIDS SINGLE NUCLEOTIDE POLYMORPHISMS
Manje Gowda Prasanna Boddupalli Kanwarpal Dhugga Vijay Chaikam (2023, [Artículo])
R1-nj Marker Embryo Rescue False Positives False Detection Rate False Negative Rate CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA DOUBLED HAPLOIDS MAIZE BREEDING PROGRAMMES INBRED LINES CROPS
Prakash Kuchanur Ayyanagouda Patil Pervez Zaidi vinayan mt (2023, [Artículo])
Multi-Parental Synthetics Rapid Cycle Genomic Selection Phenotypic Correlation CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA MAIZE HEAT STRESS MARKER-ASSISTED SELECTION DOUBLED HAPLOIDS PHENOTYPIC VARIATION CLIMATE CHANGE
RNAseq of diverse spring wheat cultivars released during last 110 years
awais rasheed Huihui Li (2023, [Artículo])
CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA RNA SEQUENCE SPRING WHEAT ROOT ARCHITECTURE GENES
Claver Ngaboyisonga Suresh L.M. (2022, [Artículo])
Additive Main Effect and Multiplicative Interaction Area Under Disease Progress Curve Maize Lethal Necrosis Variety x Environment Interaction CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA MAIZE CHLOROTIC MOTTLE VIRUS RESISTANCE VARIETIES INOCULATION DISEASE MANAGEMENT SUGARCANE MOSAIC VIRUS
JOVITO CESAR SANTOS ALVAREZ JUAN MANUEL VELAZQUEZ ENRIQUEZ ROSENDO GARCÍA CARRILLO CESAR RODRIGUEZ BEAS ALMA AURORA RAMIREZ HERNANDEZ EDILBURGA REYES JIMENEZ KARINA GONZÁLEZ GARCÍA ARMANDO LOPEZ MARTINEZ LAURA PEREZ CAMPOS MAYORAL SERGIO ROBERTO AGUILAR RUIZ MARIA DE LOS ANGELES ROMERO TLALOLINI HONORIO TORRES AGUILAR LUIS ALBERTO CASTRO SANCHEZ JAIME ARELLANES ROBLEDO VERONICA ROCIO VASQUEZ GARZON RAFAEL BALTIERREZ HOYOS (2022, [Artículo])
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease. Lesions in the lung epithelium cause alterations in the microenvironment that promote fibroblast accumulation. Extracellular vesicles (EVs) transport proteins, lipids, and nucleic acids, such as microRNAs (miRNAs). The aim of this study was to characterize the differentially expressed miRNAs in the cargo of EVs obtained from the LL97 and LL29 fibroblast cell lines isolated from IPF lungs versus those derived from the CCD19 fibroblast cell line isolated from a healthy donors. We characterized EVs by ultracentrifugation, Western blotting, and dynamic light scattering. We identified miRNAs by small RNA-seq, a total of 1144 miRNAs, of which
1027 were known miRNAs; interestingly, 117 miRNAs were novel. Differential expression analysis showed that 77 miRNAs were upregulated and 68 were downregulated. In addition, pathway enrichment analyses from the Gene Ontology and Kyoto Encyclopedia of Genomes identified several miRNA target genes in the categories, cell proliferation, regulation of apoptosis, pathways in cancer, and proteoglycans in cancer. Our data reveal that miRNAs contained in EVs cargo could be helpful as biomarkers for fibrogenesis, diagnosis, and therapeutic intervention of IPF.
MEDICINA Y CIENCIAS DE LA SALUD Idiopathic pulmonary fibrosis Extracellular vesicles Fibroblasts Small-RNA seq