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TBHQ induces a hormetic response that protects L6 myoblasts against the toxic effect of palmitate

PEDRO POSADAS RODRIGUEZ NATALIA ESMERALDA POSADAS RODRIGUEZ VIRIDIANA YAZMIN GONZALEZ PUERTOS RAFAEL TOLEDO PEREZ JOSE LUIS VENTURA GALLEGOS ALEJANDRO ZENTELLA DEHESA LUIS ENRIQUE GOMEZ QUIROZ MINA KONIGSBERG FAINSTEIN ARMANDO LUNA LOPEZ (2020)

Nutritional status, in particular overweight and obesity, as well as sedentarism and high-fat diet consumption, are important risk factors to develop chronic diseases, which have a higher impact on the elderly’s health. Therefore, these nutritional problems have become a concern to human healthspan and longevity. The fatty acids obtained thru the diet or due to fatty acid synthesis during obesity accumulate within the body generating toxicity and cell death. Fat is not only stored in adipose tissue, but it can also be stored in skeletal muscle. Palmitic acid (PA) has been reported as one of the most important saturated free fatty acids; it is associated to chronic oxidative stress and increased mitochondrial ROS production causing cell death by apoptosis. In skeletal muscle, palmitate has been associated with various pathophysiological consequences, which lead to muscle deterioration during aging and obesity. Since molecules that modify redox state have been proven to prevent cellular damage by inducing a hormetic response, the aim of this study was to evaluate if tert-butylhydroquinone (tBHQ) could activate an antioxidant hormetic response that would be able to protect L6 myoblasts from palmitate toxic effect. Our results provide evidence that tBHQ is able to protect L6 myoblasts against the toxicity induced by sodium palmitate due to a synergistic activation of different signaling pathways such as Nrf2 and NF-κB.

Article

MEDICINA Y CIENCIAS DE LA SALUD Ciencias médicas Ciencias Clínicas Nutrición Dieta, alimentación y nutrición Estado nutricional Dieta Desordenes nutricionales Obesidad Personas mayores Longevidad Diet, food and nutrition Nutritional status Diet Nutrition disorders Obesity Elderly Longevity

Efecto de la obesidad en la fertilidad masculina: estudios en modelos animales

LORENA RUIZ VALDERRAMA ROMAN ESPINOSA CERVANTES Ireri Fragoso AHIEZER RODRIGUEZ TOBON HUMBERTO GONZALEZ MARQUEZ ISABEL ARRIETA CRUZ MARIA DEL ROSARIO TARRAGO CASTELLANOS MARCELA ARTEAGA SILVA EDITH ARENAS RIOS (2016)

Resumen: En los últimos 10 años, la obesidad ha aumentado en países importantes de Latinoamérica y el resto del mundo, provocando que se preste atención a su etiología para establecer tratamientos efectivos a patologías o anormalidades en el organismo que se favorecen bajo esta condición. Dentro de estas anormalidades se encuentra la infertilidad masculina, incapacidad para que se logre un embarazo después de 1 año sin protección durante las relaciones sexuales, y que se ha situado también como un problema a nivel global. La relación entre la obesidad y la disminución de la fertilidad masculina se ha reportado en clínicas de fertilidad y en modelos experimentales. Los efectos deletéreos de la obesidad sobre algunos aspectos de la fertilidad masculina se han reportado en conejo, ratón y rata. Sin embargo, aún quedan muchos aspectos sin abordar a profundidad, es por eso que esta revisión reúne los trabajos más recientes relacionados con la obesidad y los efectos negativos sobre los aspectos, físicos, fisiológicos y bioquímicos en la reproducción masculina, realizados en los principales modelos animales, sujetos de estudio, para poder mostrar un panorama más amplio sobre este tema.

Article

MEDICINA Y CIENCIAS DE LA SALUD Ciencias médicas Ciencias de la nutrición Enfermedades de la nutrición Enfermedades nutricionales y metabólicas Desordenes nutricionales Sobrenutrición Obesidad Enfermedades urogenitales masculinas Infertilidad masculina Nutritional disorders Overnutrition Obesity Male urogenital diseases Infertility, male

Efecto de la obesidad en la fertilidad masculina: estudios en modelos animales

LORENA RUIZ VALDERRAMA ROMAN ESPINOSA CERVANTES Ireri Fragoso AHIEZER RODRIGUEZ TOBON HUMBERTO GONZALEZ MARQUEZ ISABEL ARRIETA CRUZ MARIA DEL ROSARIO TARRAGO CASTELLANOS MARCELA ARTEAGA SILVA EDITH ARENAS RIOS (2016)

Resumen: En los últimos 10 años, la obesidad ha aumentado en países importantes de Latinoamérica y el resto del mundo, provocando que se preste atención a su etiología para establecer tratamientos efectivos a patologías o anormalidades en el organismo que se favorecen bajo esta condición. Dentro de estas anormalidades se encuentra la infertilidad masculina, incapacidad para que se logre un embarazo después de 1 año sin protección durante las relaciones sexuales, y que se ha situado también como un problema a nivel global. La relación entre la obesidad y la disminución de la fertilidad masculina se ha reportado en clínicas de fertilidad y en modelos experimentales. Los efectos deletéreos de la obesidad sobre algunos aspectos de la fertilidad masculina se han reportado en conejo, ratón y rata. Sin embargo, aún quedan muchos aspectos sin abordar a profundidad, es por eso que esta revisión reúne los trabajos más recientes relacionados con la obesidad y los efectos negativos sobre los aspectos, físicos, fisiológicos y bioquímicos en la reproducción masculina, realizados en los principales modelos animales, sujetos de estudio, para poder mostrar un panorama más amplio sobre este tema.

Article

MEDICINA Y CIENCIAS DE LA SALUD Ciencias médicas Ciencias de la nutrición Enfermedades de la nutrición Enfermedades nutricionales y metabólicas Desordenes nutricionales Sobrenutrición Obesidad Enfermedades urogenitales masculinas Infertilidad masculina Nutritional disorders Overnutrition Obesity Male urogenital diseases Infertility, male

Modulation of PPAR-γ by nutraceutics as complementary treatment for obesity-related disorders and inflammatory diseases

DANIEL ORTUÑO SAHAGUN ANA LAURA MARQUEZ AGUIRRE MARIA SARAY QUINTERO FABIAN ROCIO IVETTE LOPEZ ROA ARGELIA ESPERANZA ROJAS MAYORQUIN (2012)

Abstract: A direct correlation between adequate nutrition and health is a universally accepted truth. The Western lifestyle, with a high intake of simple sugars, saturated fat, and physical inactivity, promotes pathologic conditions. The main adverse consequences range from cardiovascular disease, type 2 diabetes, and metabolic syndrome to several cancers. Dietary components influence tissue homeostasis in multiple ways and many different functional foods have been associated with various health benefits when consumed. Natural products are an important and promising source for drug discovery. Many anti-inflammatory natural products activate peroxisome proliferator-activated receptors (PPAR); therefore, compounds that activate or modulate PPAR-gamma (PPAR-γ) may help to fight all of these pathological conditions. Consequently, the discovery and optimization of novel PPAR-γ agonists and modulators that would display reduced side effects is of great interest. In this paper, we present some of the main naturally derived products studied that exert an influence on metabolism through the activation or modulation of PPAR-γ, and we also present PPAR-γ-related diseases that can be complementarily treated with nutraceutics from functional foods.

Concluding remarks: Despite the great potential benefits that nutraceutics are able to provide, one must be careful when consuming botanical and dietary supplements with anti-inflammatory and antioxidant properties when one is at risk for microbial infections. In vivo, the outcome of an infection is determined by a balance between means of host-immune defense versus those of the parasite, and antioxidants and anti-inflammatories may weaken immune defense and exacerbate the infection. Furthermore, the high prevalence of dietary supplements does not ensure that the nutrient intake of supplements would be the same among all of their consumers. The nutrient intake from dietary supplements varies in terms of the composition of the supplements. Therefore, it is urgent to meet nutrient needs by consuming foods that provide a well-balanced, nutrient-dense diet.

It is also important to engage in different types of evidence in support of the health benefits of natural products. Epidemiological information may offer the first suggestion that certain natural products, in the diets of specific populations, may exert an influence on the course of chronic diseases, such as obesity and some of its concomitant complications, such as cardiovascular diseases, diabetes, and cancer. Although the intake of certain dietary compounds indicate differences in the prevalence of some pathologies in specific groups, it does not prove that supplementation with these compounds could change the course of the pathologies. Genetic and environmental factors may all contribute to the final effects observed in a studied population.

In this paper, we carried out a detailed approach on the mechanistic and molecular interaction of nutraceutics and PPAR-γ, which has been identified as one of the major regulators of adipogenesis at a cellular level and a master regulator of energetic homeostasis. Because the use of synthetic PPAR-γ agonists has been associated with an increased risk of cardiovascular ischemic events, natural PPAR-γ ligands have been shown to ameliorate obesity-related disorders and certain inflammatory diseases. Some of these agonists could activate both PPAR-α and PPAR-γ (dual PPAR-α/PPAR-γ agonists), which might be even more effective. However, additional, extensive research of nutraceutics and their potential ability to modulate PPAR-γ in strengthening the inflammatory response network requires further study in the future. Unfortunately, there continue to be few clinical trials on these compounds and some evidences lack the molecular mechanisms. The group of evidences indicates that the effect of molecular interactions will also depend on the model studied in the laboratory. In vivo and in vitro assays have documented the biological effects on adipogenesis, inflammation, carcinogenesis, and so forth. However, additional studies should be conducted in PPAR-γ conditional mice in which the effects of nutraceutics on adipose tissues the hyperplasia and hypertrophy, adipogenetic genes modulation, and inflammatory biomarkers can be directly observed and studied.

In conclusion, although more experimental work is required to evaluate their full potential in humans, especially in terms of safety, PPAR natural agonists nonetheless represent a promising strategy for mitigating obesity-related disorders and some inflammatory diseases, reducing the side effects exhibited by the commonly used pharmacological drugs. However, more randomized controlled trials are needed for nutraceutics that, in agreement with epidemiological and mechanistic evidence assays, could be good candidates for or against a specific pathology. Additionally, surprising results of increased disease risk with the consumption of some natural products have been found. Therefore, unless safety profiles for nutraceutical supplements in humans are available, caution should be used in their long-term use as PPAR-γ modulators.

Article

MEDICINA Y CIENCIAS DE LA SALUD Ciencias médicas Ciencias de la nutrición Enfermedades nutricionales y metabólicas Nutritional and metabolic diseases Nutrition disorders (pathology) Desordenes nutricionales (patología)

Modulation of PPAR-γ by nutraceutics as complementary treatment for obesity-related disorders and inflammatory diseases

DANIEL ORTUÑO SAHAGUN ANA LAURA MARQUEZ AGUIRRE MARIA SARAY QUINTERO FABIAN ROCIO IVETTE LOPEZ ROA ARGELIA ESPERANZA ROJAS MAYORQUIN (2012)

Abstract: A direct correlation between adequate nutrition and health is a universally accepted truth. The Western lifestyle, with a high intake of simple sugars, saturated fat, and physical inactivity, promotes pathologic conditions. The main adverse consequences range from cardiovascular disease, type 2 diabetes, and metabolic syndrome to several cancers. Dietary components influence tissue homeostasis in multiple ways and many different functional foods have been associated with various health benefits when consumed. Natural products are an important and promising source for drug discovery. Many anti-inflammatory natural products activate peroxisome proliferator-activated receptors (PPAR); therefore, compounds that activate or modulate PPAR-gamma (PPAR-γ) may help to fight all of these pathological conditions. Consequently, the discovery and optimization of novel PPAR-γ agonists and modulators that would display reduced side effects is of great interest. In this paper, we present some of the main naturally derived products studied that exert an influence on metabolism through the activation or modulation of PPAR-γ, and we also present PPAR-γ-related diseases that can be complementarily treated with nutraceutics from functional foods.

Concluding remarks: Despite the great potential benefits that nutraceutics are able to provide, one must be careful when consuming botanical and dietary supplements with anti-inflammatory and antioxidant properties when one is at risk for microbial infections. In vivo, the outcome of an infection is determined by a balance between means of host-immune defense versus those of the parasite, and antioxidants and anti-inflammatories may weaken immune defense and exacerbate the infection. Furthermore, the high prevalence of dietary supplements does not ensure that the nutrient intake of supplements would be the same among all of their consumers. The nutrient intake from dietary supplements varies in terms of the composition of the supplements. Therefore, it is urgent to meet nutrient needs by consuming foods that provide a well-balanced, nutrient-dense diet.

It is also important to engage in different types of evidence in support of the health benefits of natural products. Epidemiological information may offer the first suggestion that certain natural products, in the diets of specific populations, may exert an influence on the course of chronic diseases, such as obesity and some of its concomitant complications, such as cardiovascular diseases, diabetes, and cancer. Although the intake of certain dietary compounds indicate differences in the prevalence of some pathologies in specific groups, it does not prove that supplementation with these compounds could change the course of the pathologies. Genetic and environmental factors may all contribute to the final effects observed in a studied population.

In this paper, we carried out a detailed approach on the mechanistic and molecular interaction of nutraceutics and PPAR-γ, which has been identified as one of the major regulators of adipogenesis at a cellular level and a master regulator of energetic homeostasis. Because the use of synthetic PPAR-γ agonists has been associated with an increased risk of cardiovascular ischemic events, natural PPAR-γ ligands have been shown to ameliorate obesity-related disorders and certain inflammatory diseases. Some of these agonists could activate both PPAR-α and PPAR-γ (dual PPAR-α/PPAR-γ agonists), which might be even more effective. However, additional, extensive research of nutraceutics and their potential ability to modulate PPAR-γ in strengthening the inflammatory response network requires further study in the future. Unfortunately, there continue to be few clinical trials on these compounds and some evidences lack the molecular mechanisms. The group of evidences indicates that the effect of molecular interactions will also depend on the model studied in the laboratory. In vivo and in vitro assays have documented the biological effects on adipogenesis, inflammation, carcinogenesis, and so forth. However, additional studies should be conducted in PPAR-γ conditional mice in which the effects of nutraceutics on adipose tissues the hyperplasia and hypertrophy, adipogenetic genes modulation, and inflammatory biomarkers can be directly observed and studied.

In conclusion, although more experimental work is required to evaluate their full potential in humans, especially in terms of safety, PPAR natural agonists nonetheless represent a promising strategy for mitigating obesity-related disorders and some inflammatory diseases, reducing the side effects exhibited by the commonly used pharmacological drugs. However, more randomized controlled trials are needed for nutraceutics that, in agreement with epidemiological and mechanistic evidence assays, could be good candidates for or against a specific pathology. Additionally, surprising results of increased disease risk with the consumption of some natural products have been found. Therefore, unless safety profiles for nutraceutical supplements in humans are available, caution should be used in their long-term use as PPAR-γ modulators.

Article

MEDICINA Y CIENCIAS DE LA SALUD Ciencias médicas Ciencias de la nutrición Enfermedades nutricionales y metabólicas Nutritional and metabolic diseases Nutrition disorders (pathology) Desordenes nutricionales (patología)

Modulation of PPAR-γ by nutraceutics as complementary treatment for obesity-related disorders and inflammatory diseases

DANIEL ORTUÑO SAHAGUN ANA LAURA MARQUEZ AGUIRRE MARIA SARAY QUINTERO FABIAN ROCIO IVETTE LOPEZ ROA ARGELIA ESPERANZA ROJAS MAYORQUIN (2012)

Abstract: A direct correlation between adequate nutrition and health is a universally accepted truth. The Western lifestyle, with a high intake of simple sugars, saturated fat, and physical inactivity, promotes pathologic conditions. The main adverse consequences range from cardiovascular disease, type 2 diabetes, and metabolic syndrome to several cancers. Dietary components influence tissue homeostasis in multiple ways and many different functional foods have been associated with various health benefits when consumed. Natural products are an important and promising source for drug discovery. Many anti-inflammatory natural products activate peroxisome proliferator-activated receptors (PPAR); therefore, compounds that activate or modulate PPAR-gamma (PPAR-γ) may help to fight all of these pathological conditions. Consequently, the discovery and optimization of novel PPAR-γ agonists and modulators that would display reduced side effects is of great interest. In this paper, we present some of the main naturally derived products studied that exert an influence on metabolism through the activation or modulation of PPAR-γ, and we also present PPAR-γ-related diseases that can be complementarily treated with nutraceutics from functional foods.

Concluding remarks: Despite the great potential benefits that nutraceutics are able to provide, one must be careful when consuming botanical and dietary supplements with anti-inflammatory and antioxidant properties when one is at risk for microbial infections. In vivo, the outcome of an infection is determined by a balance between means of host-immune defense versus those of the parasite, and antioxidants and anti-inflammatories may weaken immune defense and exacerbate the infection. Furthermore, the high prevalence of dietary supplements does not ensure that the nutrient intake of supplements would be the same among all of their consumers. The nutrient intake from dietary supplements varies in terms of the composition of the supplements. Therefore, it is urgent to meet nutrient needs by consuming foods that provide a well-balanced, nutrient-dense diet.

It is also important to engage in different types of evidence in support of the health benefits of natural products. Epidemiological information may offer the first suggestion that certain natural products, in the diets of specific populations, may exert an influence on the course of chronic diseases, such as obesity and some of its concomitant complications, such as cardiovascular diseases, diabetes, and cancer. Although the intake of certain dietary compounds indicate differences in the prevalence of some pathologies in specific groups, it does not prove that supplementation with these compounds could change the course of the pathologies. Genetic and environmental factors may all contribute to the final effects observed in a studied population.

In this paper, we carried out a detailed approach on the mechanistic and molecular interaction of nutraceutics and PPAR-γ, which has been identified as one of the major regulators of adipogenesis at a cellular level and a master regulator of energetic homeostasis. Because the use of synthetic PPAR-γ agonists has been associated with an increased risk of cardiovascular ischemic events, natural PPAR-γ ligands have been shown to ameliorate obesity-related disorders and certain inflammatory diseases. Some of these agonists could activate both PPAR-α and PPAR-γ (dual PPAR-α/PPAR-γ agonists), which might be even more effective. However, additional, extensive research of nutraceutics and their potential ability to modulate PPAR-γ in strengthening the inflammatory response network requires further study in the future. Unfortunately, there continue to be few clinical trials on these compounds and some evidences lack the molecular mechanisms. The group of evidences indicates that the effect of molecular interactions will also depend on the model studied in the laboratory. In vivo and in vitro assays have documented the biological effects on adipogenesis, inflammation, carcinogenesis, and so forth. However, additional studies should be conducted in PPAR-γ conditional mice in which the effects of nutraceutics on adipose tissues the hyperplasia and hypertrophy, adipogenetic genes modulation, and inflammatory biomarkers can be directly observed and studied.

In conclusion, although more experimental work is required to evaluate their full potential in humans, especially in terms of safety, PPAR natural agonists nonetheless represent a promising strategy for mitigating obesity-related disorders and some inflammatory diseases, reducing the side effects exhibited by the commonly used pharmacological drugs. However, more randomized controlled trials are needed for nutraceutics that, in agreement with epidemiological and mechanistic evidence assays, could be good candidates for or against a specific pathology. Additionally, surprising results of increased disease risk with the consumption of some natural products have been found. Therefore, unless safety profiles for nutraceutical supplements in humans are available, caution should be used in their long-term use as PPAR-γ modulators.

Article

MEDICINA Y CIENCIAS DE LA SALUD Ciencias médicas Ciencias de la nutrición Enfermedades nutricionales y metabólicas Nutritional and metabolic diseases Nutrition disorders (pathology) Desordenes nutricionales (patología)

Modelo ontológico para la representación de desórdenes de conducta en infantes

ANDREA MONICA PAOLA TAMBORRELL HERNANDEZ (2017)

"Los desórdenes de conducta son un comportamiento de patrones persistentes en niños y adolescentes en presencia de los cuales los derechos de otros o reglas básicas son quebrantados. Considerando este problema, se propone la creación de un modelo ontológico para el tratamiento espacial de desórdenes de conducta en el idioma español. Este modelo ontológico está basado en la interacción de ontologías individuales, el cual permitirá responder a consultas espaciales basadas en semántica, tales como lugares de incidencia de cierto trastorno de conducta o interacciones medicamentosas en el tratamiento de cierto problema de conducta. En el diseño del modelo se aplican los conceptos de reusabilidad e integración de ontologías las cuales han sido individualmente axiomatizadas para lograr consistencia del sistema."

Benemérita Universidad Autónoma de Puebla

Master thesis

Desórdenes del comportamiento Ontología (Recuperación de datos) INGENIERÍA Y TECNOLOGÍA

Etiología del canino maxilar desplazado por palatino

GASPAR REYES PEART (2017)

"El tema de caninos desplazados por palatino, a través de los años se ha convertido en una gran controversia sobre todo a la hora de proponer un diagnóstico y un plan de tratamiento. El interés en este tema despierta cuando se recibe un paciente de sexo femenino de 11 años de edad en el posgrado de ortodoncia de la Facultad de Estomatología de la Benemérita Universidad Autónoma de Puebla. A la evaluación clínica se observó un estadío de dentición mixta con mordida cruzada anterior y posterior unilateral, resaltando la ausencia clínica de los caninos permanentes superiores."

Benemérita Universidad Autónoma de Puebla

Master thesis

Desórdenes de la dentición Ortodoncia--Tratamiento MEDICINA Y CIENCIAS DE LA SALUD

Nitric oxide donors as neuroprotective agents after an ischemic stroke-related inflammatory reaction

JULIANA MARISOL GODINEZ RUBI ARGELIA ESPERANZA ROJAS MAYORQUIN DANIEL ORTUÑO SAHAGUN (2013)

La isquemia cerebral inicia una cascada de eventos perjudiciales, incluyendo la excitotoxicidad asociada al glutamato, la acumulación de calcio intracelular, la formación de especies de oxígeno reactivo (ROS), la degradación de los lípidos de membrana y el daño del ADN, que conducen a la alteración de la homeostasis celular y daño estructural del tejido isquémico cerebral . La isquemia cerebral también desencadena una inflamación aguda, que exacerba el daño cerebral primario. Por lo tanto, la reducción del estrés oxidativo (SO) y la regulación negativa de la respuesta inflamatoria son opciones que merecen ser consideradas como potenciales dianas terapéuticas para el accidente cerebrovascular isquémico. En consecuencia, los agentes capaces de modular ambos elementos constituirán soluciones terapéuticas prometedoras porque aún no se han descubierto neuroprotectores clínicamente eficaces y hasta la fecha no hay terapia específica para el accidente cerebrovascular. Debido a su capacidad para modular tanto el estrés oxidativo como la respuesta inflamatoria, se ha prestado mucha atención al papel de los donantes de óxido nítrico (NOD) como agentes neuroprotectores en la fisiopatología de la lesión por isquemia-reperfusión cerebral. Dada su breve ventana terapéutica, el NOD parece ser apropiado para el uso durante procedimientos neuroquirúrgicos que implican oclusiones arteriales transitorias, o en tratamiento muy temprano del ictus isquémico agudo, y también posiblemente como tratamiento complementario para enfermedades neurodegenerativas como Parkinson o Alzheimer, donde el estrés oxidativo es Un importante promotor de daños. En el presente trabajo, nos centramos en el papel de NOD como posibles agentes neuroprotectores terapéuticos para el tratamiento de isquemia / reperfusión.

Article

BIOLOGÍA Y QUÍMICA Ciencias de la vida Neurociencias Neurofisiología Desordenes cerebrovasculares Isquemia cerebral Citología Agentes cardiovasculares Donadores de óxido nítrico Neurosciences Neurophysiology Cerebrovascular disorders Brain ischemia Cytology

Neuropsychiatric symptoms distress comparison between caregivers of Alzheimer disease and frontolobar degeneration patients

FRANCISCO LEONARDO RAMIREZ CUAPIO ADRIAN MARTINEZ RUIZ Ana Luisa Sosa Ortiz (2016)

Abstract:

Background

African Americans are twice more likely to be diagnosed with Alzheimer’s than other ethnic groups; therefore, African American, family caregivers will face a greater burden in Alzheimer’s care management, health access and health outcomes. Research has also shown that African American spouses (as caregivers) and female caregivers are at higher risk of experiencing task difficulty, depressive symptoms and negative life changes as a result of providing care. This data emphasizes the need to understand the experiences, needs and perceptions of African American informal caregivers of people with Alzheimer’s. The goal of this descriptive study was to assess the needs of caregivers, their perceived burdens and the role that gender may play in caregiving in a community dwelling cohort of African American caregivers.

Methods

We conducted a needs assessment with a convenience sample of more than 400 African American caregivers that attended an annual caregivers education conference sponsored by a community outreach center in the Southeast region of the United States. We designed and administered a 27 question survey that assessed caregivers’ workload, self-reported health, their need for resources, as well as self-reported troublesome behaviors.

Results

We received 167 completed surveys 138 of which were from informal or family caregivers. Our findings indicate that nearly one-half of caregivers reported working full-time while simultaneously providing 10 to more than 40 hours of care per week for a loved one. Male caregivers reported needing more help with finances and finding either adult day care, nursing homes or nurse aides while female caregivers reported needing resources on how to have family discussions, how to find adult day care and finances. Both females and males reported that combativeness was the most problematic behavior exhibited by their loved one. More than 70% reported feeling well most days and expressed interest in receiving more caregiver training.

Conclusions:

In general, African Americans are thought to be resilient caregivers. Unfortunately, stress from caregiving, in many cases, leads to poor health outcomes for caregivers. This data provides information to design interventions that are tailored to the needs of the caregivers and their affected family members.

Article

MEDICINA Y CIENCIAS DE LA SALUD Ciencias médicas Psiquiatría Psicopatología Desordenes mentales Desordenes neurocognitivos Demencia Alzheimer, Enfermedad de Cuidadores Mental disorders Neurocognitive disorders Dementia Alzheimer disease Caregivers