Suppression of breast tumor growth and metastasis by an engineered transcription factor

Adriana Beltran Lopez (2011, [Artículo])

Maspin is a tumor and metastasis suppressor playing an essential role as gatekeeper of tumor progression. It is highly expressed in epithelial cells but is silenced in the onset of metastatic disease by epigenetic mechanisms. Reprogramming of Maspin epigenetic silencing offers a therapeutic potential to lock metastatic progression. Herein we have investigated the ability of the Artificial Transcription Factor 126 (ATF-126) designed to upregulate the Maspin promoter to inhibit tumor progression in pre-established breast tumors in immunodeficient mice. ATF-126 was transduced in the aggressive, mesenchymal-like and triple negative breast cancer line, MDA-MB-231. Induction of ATF expression in vivo by Doxycycline resulted in 50% reduction in tumor growth and totally abolished tumor cell colonization. Genome-wide transcriptional profiles of ATF-induced cells revealed a gene signature that was found over-represented in estrogen receptor positive (ER+) "Normal-like" intrinsic subtype of breast cancer and in poorly aggressive, ER+ luminal A breast cancer cell lines. The comparison transcriptional profiles of ATF-126 and Maspin cDNA defined an overlapping 19-gene signature, comprising novel targets downstream the Maspin signaling cascade. Our data suggest that Maspin up-regulates downstream tumor and metastasis suppressor genes that are silenced in breast cancers, and are normally expressed in the neural system, including CARNS1, SLC8A2 and DACT3. In addition, ATF-126 and Maspin cDNA induction led to the re-activation of tumor suppressive miRNAs also expressed in neural cells, such as miR-1 and miR-34, and to the down-regulation of potential oncogenic miRNAs, such as miR-10b, miR-124, and miR-363. As expected from its over-representation in ER+ tumors, the ATF-126-gene signature predicted favorable prognosis for breast cancer patients. Our results describe for the first time an ATF able to reduce tumor growth and metastatic colonization by epigenetic reactivation of a dormant, normal-like, and more differentiated gene program. © 2011 Beltran et al.

artificial transcription factor 126, complementary DNA, doxycycline, estrogen receptor, maspin, microRNA, retrovirus vector, transcription factor, unclassified drug, estrogen receptor, serine proteinase inhibitor, SERPIN B5, SERPIN-B5, transcription BIOLOGÍA Y QUÍMICA CIENCIAS DE LA VIDA BIOLOGÍA ANIMAL (ZOOLOGÍA) BIOLOGÍA ANIMAL (ZOOLOGÍA)

Genetic analysis of Vibrio parahaemolyticus O3:K6 strains that have been isolated in Mexico since 1998

CARLOS ABRAHAM GUERRERO RUIZ (2017, [Artículo])

Vibrio parahaemolyticus is an important human pathogen that has been isolated worldwide from clinical cases, most of which have been associated with seafood consumption. Environmental and clinical toxigenic strains of V. parahaemolyticus that were isolated in Mexico from 1998 to 2012, including those from the only outbreak that has been reported in this country, were characterized genetically to assess the presence of the O3:K6 pandemic clone, and their genetic relationship to strains that are related to the pandemic clonal complex (CC3). Pathogenic tdh+ and tdh+/trh+ strains were analyzed by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). Also, the entire genome of a Mexican O3:K6 strain was sequenced. Most of the strains were tdh/ORF8-positive and corresponded to the O3:K6 serotype. By PFGE and MLST, there was very close genetic relationship between ORF8/O3:K6 strains, and very high genetic diversities from non-pandemic strains. The genetic relationship is very close among O3:K6 strains that were isolated in Mexico and sequences that were available for strains in the CC3, based on the PubMLST database. The whole-genome sequence of CICESE-170 strain had high similarity with that of the reference RIMD 2210633 strain, and harbored 7 pathogenicity islands, including the 4 that denote O3:K6 pandemic strains. These results indicate that pandemic strains that have been isolated in Mexico show very close genetic relationship among them and with those isolated worldwide. © 2017 Guerrero et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Article, bacterial strain, biofouling, controlled study, Crassostrea, food intake, gene sequence, genetic analysis, genetic variability, Japan, Mexican, Mexico, molecular phylogeny, nonhuman, pandemic, pathogenicity island, sea food, serotyping, toxi BIOLOGÍA Y QUÍMICA CIENCIAS DE LA VIDA GENÉTICA GENÉTICA

Physiological ecology of Mexican CAM plants: history, progress, and opportunities

Joel David Flores Rivas Oscar Briones Villareal JOSE LUIS ANDRADE (2022, [Artículo])

"In Mexico, plants with crassulacean acid metabolism (CAM) are part of the Mexican culture, have different uses and are even emblematic. Unfortunately, only a small fraction of the Mexican CAM plants has been studied physiologically. For this review, the following questions were considered: What ecophysiological studies have been conducted with CAM species native to Mexico? What ecophysiological processes in Mexican CAM plants are the most studied? What type of ecophysiological studies with CAM plants are still needed? A database of scientific studies on CAM plant species from Mexico was documented, including field and laboratory works for species widely distributed, and those studies made outside Mexico with Mexican species. Physiological processes were grouped as germination, photosynthesis, and water relations. Most studies were done for CAM species of Cactaceae, Bromeliaceae, Asparagaceae and Orchidaceae, andmost ecophysiological studies have been done on germination of cacti. Field and laboratory studies on photosynthesis and water relations were mostly for terrestrial cacti and epiphytic bromeliads. There were few physiological studies with CAM seedlings in Mexico and few studies using stable isotopes of water and carbon of CAM plants in the field. More field and laboratory studies of physiological responses and plasticity of CAM plants to multiple stress factors are required to model plant responses to global climate change. In general, more physiological studies are essential for all CAM species and for species of the genus Clusia, with C3-CAM and CAM members, which can become ecologically important under some climate change scenarios."

Asparagaceae Bromeliaceae Cactaceae Germination Photosynthesis Water relations Orchidaceae BIOLOGÍA Y QUÍMICA CIENCIAS DE LA VIDA BIOLOGÍA VEGETAL (BOTÁNICA) BIOLOGÍA VEGETAL (BOTÁNICA)

Shopping for Ecological Indices? On the Use of Incidence-Based Species Compositional Similarity Measures

IAN MACGREGOR FORS FEDERICO ESCOBAR SARRIA JUAN FERNANDO ESCOBAR IBAÑEZ NATALIA MESA SIERRA FREDY ALEXANDER ALVARADO ROBERTO Rafael Rueda Hernández CLAUDIA ELIZABETH MORENO ORTEGA Ina Falfán ERICK JOAQUIN CORRO MENDEZ Eduardo Octavio Pineda Arredondo Amandine Bourg JOSE LUIS AGUILAR LOPEZ (2022, [Artículo])

"β-diversity has been under continuous debate, with a current need to better understand the way in which a new wave of measures work. We assessed the results of 12 incidence-based β-diversity indices. Our results of gradual species composition overlap between paired assemblages considering progressive differences in species richness show the following: (i) four indices (β-2, β-3, β-3.s, and βr) should be used cautiously given that results with no shared species retrieve results that could be misinterpreted; (ii) all measures conceived specifically as partitioned components of species compositional dissimilarities ought to be used as such and not as independent measures per se; (iii) the non-linear response of some indices to gradual species composition overlap should be interpreted carefully, and further analysis using their results as dependent variables should be performed cautiously; and (iv) two metrics (βsim and βsor) behave predictably and linearly to gradual species composition overlap. We encourage ecologists using measures of β-diversity to fully understand their mathematical nature and type of results under the scenario to be used in order to avoid inappropriate and misleading inferences."

Beta diversity Nestedness Replacement Richness difference Species turnover BIOLOGÍA Y QUÍMICA CIENCIAS DE LA VIDA BIOLOGÍA VEGETAL (BOTÁNICA) ECOLOGÍA VEGETAL ECOLOGÍA VEGETAL

Análisis de redes de coexpresión RNA-Seq para identificar patrones genéticos consenso en Arabidopsis en respuesta a la infección por hongos ascomicetes

CYNTHIA GUADALUPE SOTO CARDINUALT (2023, [Tesis de doctorado])

BIOLOGÍA Y QUÍMICA CIENCIAS DE LA VIDA BIOQUÍMICA BIOLOGÍA MOLECULAR BIOLOGÍA MOLECULAR

Estudio fitoquímico biodirigido de los componentes presentes en Diospyros anisandra S. F. Blake con potencial actividad antiviral a nivel hemaglutinina y neuraminidasa

MARI TOÑA JUAREZ MENDEZ (2021, [Tesis de doctorado])

BIOLOGÍA Y QUÍMICA CIENCIAS DE LA VIDA BIOQUÍMICA BIOLOGÍA MOLECULAR BIOLOGÍA MOLECULAR

Del bosque a la cocina: los hongos comestibles silvestres

RAUL VALLE MARQUINA ALEJANDRO GARCIA FLORES ARACELI TEGOMA COLOREANO EMIR BASURTO GARCÍA (2024, [Artículo])

La cocina mexicana es reflejo de nuestra historia, costumbres y tradiciones, así como de la biodiversidad y la cultura. En el territorio nacional se encuentra una gran variedad de ingredientes y recursos alimentarios, entre ellos, los hongos silvestres. Muchas comunidades tienen una antigua tradición asociada a su recolección, preparación, consumo y venta. En términos de nutrición, son un alimento de alta calidad y propiedades funcionales para incorporar a la dieta, pero también un importante medio de subsistencia. En este artículo se aborda el aprovechamiento tradicional de hongos comestibles silvestres en el Corredor Biológico Chichinautzin, área natural protegida ubicada al norte del estado de Morelos.

Mexican cuisine is a reflection of our history, customs and traditions, as well as biodiversity and culture. In the national territory there is a wide variety of ingredients and food resources, including wild mushrooms. Many communities have an ancient tradition associated with their collection, preparation, consumption and sale. In terms of nutrition, they are a high-quality food and functional properties to incorporate into the diet, but also an important means of subsistence. This article discusses the traditional use of wild edible mushrooms in the Chichinautzin Biological Corridor, a protected natural area located in the north of the state of Morelos.

BIOLOGÍA Y QUÍMICA CIENCIAS DE LA VIDA hongos comestibles silvestres, conocimiento tradicional, Corredor Biológico Chichinautzin, cocina tradicional mexicana

Tallo: A global tree allometry and crown architecture database

Tommaso Jucker Jörg Fischer Jerome Chave David Coomes John Caspersen Arshad Ali Grace Jopaul Loubota Panzou Ted R. Feldpausch Daniel Falster Vladimir Andreevich Usoltsev Stephen Adu-Bredu Luciana Alves Mohammad Aminpour Bhely ANGOBOY Ilondea Niels Anten Cécile Antin yousef askari Rodrigo Muñoz Ayyappan Narayanan Patricia Balvanera Lindsay Banin Nicolas Barbier John J. Battles Hans Beeckman Yannick Enock Bocko Benjamin Bond_Lamberty Frans Bongers Samuel Bowers THOMAS BRADE Michiel van Breugel ARTHUR CHANTRAIN Rajeev Chaudhary JINGYU DAI Michele Dalponte Kangbéni Dimobe jean-christophe domec Jean-Louis Doucet Remko Duursma Moisés Enriquez KARIN Y. VAN EWIJK WILLIAM FARFAN_RIOS Adeline FAYOLLE ERIC FORNI David Forrester Hammad Gilani John Godlee Sylvie Gourlet-Fleury Matthias Haeni Jefferson Hall Jie He Andreas Hemp JOSE LUIS HERNANDEZ STEFANONI Steven Higgins ROBERT J. HOLDAWAY Kiramat Hussain Lindsay Hutley Tomoaki Ichie Yoshiko Iida Hai Jiang Puspa Raj Joshi Seyed Hasan Kaboli Maryam Kazempour Larsary Tanaka Kenzo Brian Kloeppel Takashi Kohyama Suwash Kunwar Shem Kuyah Jakub Kvasnica Siliang Lin Emily Lines Hongyan Liu CRAIG LORIMER Joel Loumeto Yadvinder Malhi Peter Marshall Eskil Mattsson Radim Matula Jorge Arturo Meave del Castillo Sylvanus Mensah XIANGCHENG MI Stephane MOMO Takoudjou Glenn Moncrieff Francisco Mora Sarath Nissanka Kevin O'Hara steven pearce Raphaël Pélissier Pablo Luis Peri Pierre Ploton Lourens Poorter mohsen javanmiri pour Hassan pourbabaei JUAN MANUEL DUPUY RADA Sabina Ribeiro Ryan Casey ANVAR SANAEI Jennifer Sanger Michael Schlund Giacomo Sellan Alexander Shenkin Bonaventure Sonké Frank Sterck Martin Svatek Kentaro Takagi Anna Trugman Farman Ullah Matthew Vadeboncoeur Ahmad Valipour Mark Vanderwel Alejandra Vovides Weiwei WANG Li Qiu Christian Wirth MURRAY WOODS Wenhua Xiang Fabiano de Aquino Ximenes Yaozhan Xu TOSHIHIRO YAMADA Miguel A. Zavala (2022, [Artículo])

Data capturing multiple axes of tree size and shape, such as a tree's stem diameter, height and crown size, underpin a wide range of ecological research—from developing and testing theory on forest structure and dynamics, to estimating forest carbon stocks and their uncertainties, and integrating remote sensing imagery into forest monitoring programmes. However, these data can be surprisingly hard to come by, particularly for certain regions of the world and for specific taxonomic groups, posing a real barrier to progress in these fields. To overcome this challenge, we developed the Tallo database, a collection of 498,838 georeferenced and taxonomically standardized records of individual trees for which stem diameter, height and/or crown radius have been measured. These data were collected at 61,856 globally distributed sites, spanning all major forested and non-forested biomes. The majority of trees in the database are identified to species (88%), and collectively Tallo includes data for 5163 species distributed across 1453 genera and 187 plant families. The database is publicly archived under a CC-BY 4.0 licence and can be access from: https://doi.org/10.5281/zenodo.6637599. To demonstrate its value, here we present three case studies that highlight how the Tallo database can be used to address a range of theoretical and applied questions in ecology—from testing the predictions of metabolic scaling theory, to exploring the limits of tree allometric plasticity along environmental gradients and modelling global variation in maximum attainable tree height. In doing so, we provide a key resource for field ecologists, remote sensing researchers and the modelling community working together to better understand the role that trees play in regulating the terrestrial carbon cycle. © 2022 The Authors. Global Change Biology published by John Wiley & Sons Ltd.

ALLOMETRIC SCALING CROWN RADIUS FOREST BIOMASS STOCKS FOREST ECOLOGY REMOTE SENSING STEM DIAMETER TREE HEIGHT BIOLOGÍA Y QUÍMICA CIENCIAS DE LA VIDA BIOLOGÍA VEGETAL (BOTÁNICA) ECOLOGÍA VEGETAL ECOLOGÍA VEGETAL

UNA ESPECIE NUEVA DE ESCOBEDIA (OROBANCHACEAE), DEL ESTADO DE MICHOACÁN, MÉXICO

ELEAZAR CARRANZA GONZALEZ MARIA DEL CONSUELO MEDINA GARCIA (2008, [Artículo])

Se describe como nueva a Escobedia michoacana (Orobanchaceae), encontrada en Michoacán, México. También se presenta una ilustración de la misma, una pequeña discusión de las posibles relaciones que guarda con otras especies del género y una clave para determinar los componentes de Escobedia que se reconocen para México. Se trata de una planta aparentemente escasa y restringida a la porción noroccidental del estado, aunque probablemente se encuentre también en Jalisco. Difiere de las demás especies mexicanas del género, por presentar cinco (no diez) nervaduras principales que corren a manera de costillas a lo largo del cáliz.

BIOLOGÍA Y QUÍMICA CIENCIAS DE LA VIDA BIOLOGÍA VEGETAL (BOTÁNICA) BOTÁNICA GENERAL BOTÁNICA GENERAL

Plants of the Popol vuh, the sacred book of the Maya

Plantas del Popol Vuh, el libro sagrado de los Mayas

CANDELARIA ISABEL PEREZ MARTIN SIGFREDO EDMUNDO ESCALANTE REBOLLEDO SILVIA VERGARA YOISURA FRANCISCO ALFONSO LARQUE SAAVEDRA (2022, [Artículo])

A compilation of the plants mentioned in the sacred book of the Mayans Popol Vuh, recognized as the framework of their cosmogony that was written in the K’iche’ area in Guatemala around the year 1550 was made. Thirty-two different species were identified, from 21 plant families, all native to Mesoamerica. The largest number of species was in Fabaceae with four species, Moraceae and Solanaceae with three species each, in addition to Bromeliaceae, Cucurbitaceae, Malvaceae and Poaceae with two species each. The five most important and frequently named species are maize (Zea mays), jícaro (Crescentia cujete), copal (Protium copal), rubber (Castilla elastica) and cocoa (Theobroma cacao). Eleven species were identified, such as pito wood (Erythrina berteroana) and zibak (Cyperus canus), considered of cosmogonic significance and food plants that are integrated into five groups: fruit trees [zapote (Manilkara zapota), nance (Byrsonima crassifolia), jocote (Spondias mombin), anona (Annona reticulata), matasano (Casimiroa edulis)], grains and seeds [maize, beans (Phaseolus lunatus), cocoa, pataxte (Theobroma bicolor)], vegetables [squash (Cucurbita moschata), tomato (Solanum lycopersicum), chilacayote (Cucurbita ficifolia)], flavourings [chili (Capsicum annuum)], and beverages [maguey (Agave americana)]. Seven species were domesticated: maize, squash, chilacayote, tobacco (Nicotiana tabacum), beans, tomato and cocoa and others for medicinal purposes, fuel and instruments. The description of the creation of man asserts the close relationship of the Mayan culture with plant biodiversity; moreover, the famous milpa, a multi-species Mesoamerican agroecosystem is mentioned that was practiced by their gods © 2022. Revista Fitotecnia Mexicana.All Rights Reserved.

COSMOGONY MILPA PLANT FAMILIES POPOL VUH SACRED BOOK SPECIES BIOLOGÍA Y QUÍMICA CIENCIAS DE LA VIDA BIOLOGÍA VEGETAL (BOTÁNICA) PALEOBOTÁNICA PALEOBOTÁNICA