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Antigiardial activity of Cupania dentata Bark and its constituents

LUIS IGNACIO HERNANDEZ CHAVEZ LUIS WILIUNFO TORRES TAPIA PAULINO SIMA POLANCO ROBERTO MANUEL CEDILLO RIVERA ROSA ESTHER MOO PUC SERGIO RUBEN PERAZA SANCHEZ (2012)

The MeOH extract of Cupania dentata bark (Sapindaceae) as well as its hexane, CH 2Cl 2, EtOAc, and BuOH fractions showed high activity against Giardia lamblia trophozoites (IC 50 = 2.12-9.52 μg/mL). The phytochemical study of fractions resulted in the isolation of taraxerone (1), taraxerol (2), scopoletin (3), and two mixtures of steroidal compounds. Taraxerone was the metabolite with the highest giardicidal activity (IC 50 = 11.33 μg/mL). 

Article

CUPANIA DENTATA GIARDICIDAL ACTIVITY SAPINDACEAE SCOPOLETIN STEROLS TA-RAXERONE TARAXEROL BIOLOGÍA Y QUÍMICA