¡El autismo sí se ve! LAS TRAYECTORIAS PARA LLEGAR A UN DIAGNÓSTICO Y A LA ATENCIÓN DE UN NIÑO/NIÑA DENTRO DEL ESPECTRO AUTISTA EN CIUDAD DE MEXICO

Angela Patricia Melo Ospina (2024, [Tesis de maestría])

“La frase “el autismo sí se ve”, busca reivindicar la experiencia del padecer de las cuidadoras y los cuidadores de niños y niñas con autismo, la cual en muchos casos es subestimada y menospreciada por el personal de salud, los maestros y por la sociedad en general, pues no hay rasgos físicos aparentes que den cuenta de esta condición, por lo que asumen que el niño o niña no presenta ningún síntoma y llegan a culpabilizar a los padres de los cambios de conducta o de los retrasos en el desarrollo, lo cual implica una demora en el diagnóstico y en la atención. Esta frase busca dar cuenta de la necesidad de que los cuidadores y las cuidadoras sean escuchadas para poder recibir una atención oportuna y de calidad. En mi investigación definí como propósito reconstruir las trayectorias para el diagnóstico y la atención de niños y niñas diagnosticados con autismo en Ciudad de México, dando cuenta de las representaciones y prácticas que tiene las y los cuidadores frente a esta condición y respecto a los diferentes recursos de atención a los que acceden. Desarrolle el trabajo de campo en Ciudad de México durante el segundo periodo de 2022; realicé observación participativa y entrevistas semiestructuradas principalmente con cuidadores y cuidadoras primarias de niños y niñas en condición del espectro autista, las cuales reciben atención terapéutica u orientación en el Consultorio de Salud Mental de Tuxpan y en la asociación Apapache Autismo, ubicados en la colonia Cuauhtémoc. De manera complementaria entrevisté a activistas en pro de los derechos de las y los cuidadores y de las personas con autismo, a adultos autistas y a terapeutas”.

Autismo en niños - México - Ciudad de México. Trastornos del Espectro Autista - Terapia. Autismo - Aspectos sociales. Familiares cuidadores - Aspectos psicológicos. Familiares cuidadores - Salud mental. Autismo en niños - Cuidado y tratamiento. Tesis - Maestría en Antropología Social, CDMX. CIENCIAS SOCIALES SOCIOLOGÍA PROBLEMAS SOCIALES ENFERMEDAD ENFERMEDAD

Desarrollo de nanocompositos de cápside viral P22 para la terapia con profármacos enzimáticos en cáncer de mama

Development of P22 viral capsid nanocomposites for enzymatic prodrug therapy in breast cancer

Astrid Rebeca Luna Rios (2024, [Tesis de maestría])

Las estrategias actuales contra el cáncer de mama presentan limitaciones debido a la falta de selectividad, disminuyendo su efectividad. La mayoría de los fármacos, como el tamoxifeno, requieren la activación metabólica por parte de las enzimas de la familia citocromo P450 (CYP) para ejercer mayores efectos anticancerígenos. Sin embargo, la concentración del CYP es variable y baja en las células tumorales, especialmente en el cáncer de mama, lo que provoca efectos secundarios. En la terapia de activación enzimática de profármacos (EPT), las enzimas se dirigen al tumor para transformar el profármaco, lo que normalmente implica la administración de la enzima seguida del profármaco. Sin embargo, las diferencias entre la farmacocinética y farmacodinamia son un obstáculo para mejorar el tratamiento. Por lo tanto, la administración conjunta de profármaco y enzima es esencial para garantizar su interacción favorable en el tumor. Este trabajo reporta una nueva clase de nanocompositos terapéuticos basados en partículas tipo virus P22 confinando CYP, funcionalizadas superficialmente con glucosa oxidasa (GOx) que transforma la glucosa en D-glucono-δ-lactona produciendo H2O2, el aceptor final de electrones en la transformación de tamoxifeno mediado por CYP, y conjugadas con un derivado de tamoxifeno como profármaco y ligando dirigido utilizando polietilenglicol como conector. En un microambiente tumoral rico en glucosa, estos nanocompuestos pueden producir fármaco activo in situ. Se caracterizaron las propiedades fisicoquímicas y la catálisis secuencial mediada por glucosa de los nanocompositos. Los estudios in vitro demostraron una disminución en la viabilidad celular en líneas celulares de cáncer de mama ER+ y ER-. Sin embargo, la internalización celular en ausencia de glucosa mostró ser preferencial con las VLPs dirigidas en ambas líneas celulares. La administración conjunta de enzimas y profármacos con una localización mejorada de las VLPs desarrolladas después de la funcionalización del tamoxifeno, lo que sugiere el potencial de los nanocompositos desarrollados para superar los desafíos existentes de la EPT y mejorar los resultados terapéuticos con efectos secundarios reducidos.

Current treatment strategies against breast cancer have limitations due to lack in selectivity. Most drugs, such as tamoxifen, require metabolic activation by cytochrome P450 (CYP) enzymes to perform greater anticancer effects. However, the concentration of CYP varies and is low in tumor cells, especially in breast cancer, resulting in side-effects. In enzyme prodrug therapy (EPT), enzymes are targeted to the tumor cells for prodrug transformation, typically involving the sequential delivery of the enzyme followed by the prodrug. However, differences in pharmacokinetics and pharmacodynamics are a major hindrance for improving treatment. Therefore, co-delivery of prodrug and enzyme is essential to ensure their favorable interaction in tumor. This work reports a new class of therapeutic nanocomposites based on P22 virus like particles (VLPs) confining the CYP activity, surface functionalized with glucose oxidase (GOx) that transforms glucose into D-glucono-δ-lactone producing hydrogen peroxide, the final electron acceptor in the CYP-mediated transformation of tamoxifen, and together conjugated with a tamoxifen derivative as prodrug and targeting ligand using polyethylene glycol as a linker. In glucose-rich tumor microenvironment, these nanocomposites can produce active drug in situ. The physicochemical properties and sequential glucose-mediated catalysis of the nanocomposites were characterized. In vitro studies demonstrated a decrease in cell viability in both ER+ and ER- breast cancer cell lines. However, cellular internalization in the absence of glucose showed improved uptake of targeted VLPs in both cell lines. The co-delivery of enzymes and prodrug with improved localization of developed VLPs after tamoxifen functionalization, suggests the potential of developed nanocomposites to overcome the existing challenges of EPT and improve the therapeutic outcomes with reduced side effects.

VLP-P22, Citocromo P45O, Glucosa oxidasa, Tamoxifeno, Terapia de activación enzimática de profármacos VLP-P22, Cytochrome P45O, Glucose oxidase, Tamoxifen, Enzyme prodrug therapy BIOLOGÍA Y QUÍMICA QUÍMICA QUÍMICA FARMACÉUTICA DISEÑO.SÍNTESIS Y ESTUDIO NUEVOS FÁRMACOS DISEÑO.SÍNTESIS Y ESTUDIO NUEVOS FÁRMACOS

Copper oxide nanoparticles biosynthetized Copper oxide nanoparticles biosynthetized biosynthetizedimprove germination improve germination improve germination and bioactive compounds in wheat sprouts

Hortensia Ortega OrtÍz JAZMIN MONTSERRAT GAUCIN DELGADO Pablo Preciado Rangel Manuel Fortis Hernández Luis Guillermo Hernández Montiel Efraín de la Cruz Lázaro Liliana Lara Capistrán (2022, [Artículo])

"Metal nanoparticles have many positive effects in improving crop production and productivity and allow for increased germination and rapid crop establishment under field conditions. The metallic nanoparticles applied in this study were copper oxide nanoparticles (CuONPs) biosynthesized using orange peel (Citrus X sinensis) as a reducing agent to avoid or reduce toxicity in wheat seeds and sprouts. This study determined the effect of CuONPs on germination, radicle and plumule length, as well as the production of phytochemical compounds in wheat sprouts. The seeds were treated with suspensions of CuONPs at the following concentrations: 0, 0.5, 1, 2, 4 and 6 mg mL-1. The results indicate that the use of low doses of CuONPs (0.5 mg mL-1), improved germination, vigor, plumule and radicle length, in addition to increasing the biosynthesis of phytochemical compounds in wheat shoots. A high concentration of CuONPs (6 mg mL-1) causes inhibitory effects due to Cu accumulation and phytotoxicity in plant tissue. The use of CuONPs for green synthesis is a viable alternative to obtain beneficial effects in germination and seedling development, as well as greater secondary metabolite production."

CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA CIENCIAS AGRARIAS AGROQUÍMICA REGULADORES DEL CRECIMIENTO DE LAS PLANTAS REGULADORES DEL CRECIMIENTO DE LAS PLANTAS

Plant Growth-Promoting Rhizobacteria Improve Growth and Fruit Quality of Cucumber under Greenhouse Conditions

GERARDO ZAPATA SIFUENTES Luis Guillermo Hernández Montiel Jorge Sáenz Mata Manuel Fortis Hernández EDUARDO BLANCO CONTRERAS ROBERTO GREGORIO CHIQUITO CONTRERAS Pablo Preciado Rangel (2022, [Artículo])

"Cucumber fruit is rich in fiber, carbohydrates, protein, magnesium, iron, vitamin B, vitamin C, flavonoids, phenolic compounds, and antioxidants. Agrochemical-based production of cucumber has tripled yields; however, excessive synthetic fertilization has caused problems in the accumulation of salts in the soil and has increased production costs. The objective of this study was to evaluate the effect of three strains of plant growth-promoting rhizobacteria (PGPR) on cucumber fruit growth and quality under greenhouse conditions. The rhizobacteria Pseudomonas paralactis (KBendo6p7), Sinorhizobium meliloti (KBecto9p6), and Acinetobacter radioresistens (KBendo3p1) was adjusted to 1 × 108 CFU mL−1 . The results indicated that the inoculation with PGPR improved plant height, stem diameter, root length, secondary roots, biomass, fruit size, fruit diameter, and yield, as well as nutraceutical quality and antioxidant capacity, significantly increasing the response of plants inoculated with A. radioresistens and S. meliloti in comparison to the control. In sum, our findings showed the potential functions of the use of beneficial bacteria such as PGPR for crop production to reduce costs, decrease pollution, and achieve world food safety and security."

rhizobacteria, PGPR, nutraceutical quality CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA CIENCIAS AGRARIAS AGROQUÍMICA REGULADORES DEL CRECIMIENTO DE LAS PLANTAS REGULADORES DEL CRECIMIENTO DE LAS PLANTAS

Effect of Pectimorf on the rooting ability, and morpho-physiological physiological trials of national cocoa (Theobroma cacaoL.) under different substrates

JUAN JOSE REYES PEREZ Luis Tarquino Llerena Ramos Víctor Hugo Reynel Chila Juan Antonio Torres Rodríguez FAROUK SAAD Luis Guillermo Hernández Montiel Wilmer Tezara (2022, [Artículo])

"Cocoa is an economical cash crop that is formerly planted worldwide. Cuttings are a method of vegetative propagation suitable for maintaining desirable characteristics in cocoa trees. A greenhouse experiment was performed to evaluate the optimal concentrations of Pectimorf® (0, 10, 50, and 100 mg L-1) for rooting ability and seedling establishment as well as some physiological trials of 4 months EETP-800 national cocoa cuttings grown under two different substrates (S1: 80% soil + 20% sand and S2: 70% soil + 20% sand + 10% rice husk). The data showed that in most cases there are no significant differences in vegetative growth and root characteristics as well as gas exchange parameters between the two substrates. On the other hand, the application of Pectimorf® concentration enhanced all tested traits compared to untreated plants. The most effective in this regard was 100 mg L-1, that giving the highest value of all trials. As for the interaction effect, the result also shows that the application of Pectimorf® concentration in special at 100 mg L-1 among two substrates had an additive effect on plant growth, gas exchange, and survival percentage compared to non-treated cuttings. The application of 100 mg L-1 Pectimorf® with S2 substrate produced stronger seedlings with a higher survival percentage. This protocol can be used commercially for cocoa propagation commercially."

bioregulator, cuttings, root length, photosynthesis CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA CIENCIAS AGRARIAS AGROQUÍMICA REGULADORES DEL CRECIMIENTO DE LAS PLANTAS REGULADORES DEL CRECIMIENTO DE LAS PLANTAS

Efficiency of combating property violence in the Northwest region of Mexico

Martin Flegl Eva Selene Hernández Gress (2023, [Artículo, Artículo])

The situation of violence in Mexico shows an alarming trend as the number of committed crimes increased by 10.9% in 2021 compared to 2020. In fact, 75.6% of the Mexican population perceives the insecurity. Due to the above, it is necessary to strengthen public security to combat this trend. However, the resources allocated to the public security in Mexico are limited. Although there are studies that investigate what causes the violence in Mexico, so far there is no study that measures the efficiency of combating the violence related to budgetary, human, and material resources of the public security. This article investigates the efficiency of combating the property violence in 206 municipalities in the Northwest region of Mexico through the Data Envelopment Analysis. The results show a low efficiency (56.67%) with significant differences between the states in the region. Baja California is the state with the lowest efficiency (17.61%), whereas the highest efficiency is found in Durango (67.25%). For the last, the need to carefully plan changes in the police force and the public security infrastructure was noted to improve the efficiency and the level of security.

Análisis Envolvente de Datos Delincuencia Eficiencia Municipios Seguridad pública CIENCIAS SOCIALES CIENCIAS SOCIALES Data Envelopment Analysis Delinquency Public security

Evaluación de la interferencia de iones presentes en aguas subterráneas sobre procesos de remoción de Arsénico en condiciones sulfato reductoras

Ana Laura Salinas Torres (2022, [Tesis de maestría])

El agua subterránea contaminada con As es un problema de interés global debido a que

es la principal fuente de consumo humano en zonas áridas y semi-áridas del planeta y puede

provocar importantes efectos secundarios en la salud humana. El desarrollo de tecnologías

fisicoquímicas y biológicas se ha implementado para la eliminación del As, sin embargo, la

presencia de algunos iones disueltos en las aguas naturales, puede afectar la eficiencia de

remoción como se ha observado en distintos estudios de adsorción, intercambio catiónico,

electrocoagulación, etc. El objetivo del presente estudio fue evaluar el efecto individual y

combinado de iones como el Na+, Ca2+, Mg2+, NO3

- y F-

, en procesos de remoción de arsénico

en condiciones sulfato reductoras, empleando hierro elemental como único donador de

electrones.

Para ello, se obtuvo un lodo anaerobio procedente de la planta tratadora de aguas

residuales de la localidad de Chihuahua, el cual fue acondicionado y activado durante 141 días,

previos al montaje del experimento. La evaluación del efecto individual y combinado se realizó

en ensayos en lote con agua subterránea sintética, donde se adicionaron 0.2 mg/L As5+, la

cantidad necesaria de soluciones patrón para obtener concentraciones similares a las reportadas

en estudios de caracterización de agua en la región de Chihuahua, ZVI como donador de

electrones y 10% v/v de lodo anaerobio. Durante los ensayos, se determinó el consumo de

sulfato por precipitación con BaCl2, así como la concentración de arsénico total por ICP

acoplado a un nebulizador ultrasónico para conocer la eficiencia de remoción. En los

tratamientos con el ión F-

, también se determinó ese ion utilizando un potenciómetro acoplado

a un electrodo de ion selectivo.

Agua subterránea contaminada As INGENIERÍA Y TECNOLOGÍA CIENCIAS TECNOLÓGICAS INGENIERÍA Y TECNOLOGÍA DEL MEDIO AMBIENTE CONTROL DE LA CONTAMINACIÓN DEL AGUA CONTROL DE LA CONTAMINACIÓN DEL AGUA

Growth Promoting Activity of Annona muricata L. Leaf Extracts on Lactobacillus casei

NIMCY NOEMI MEZA GUTIERREZ Paola Magallón Servín ROSENDO BALOIS MORALES IZA FERNANDA PEREZ RAMIREZ GRACIELA GUADALUPE LOPEZ GUZMAN GUILLERMO BERUMEN VARELA Pedro Ulises Bautista Rosales (2022, [Artículo])

"Soursop leaves are a source of phytochemical compounds, such as phenolic acids, flavonoids, hydrolyzable tannins, and acetogenins. These compounds can have several types of biological activities. Lactic acid bacteria can uptake phenolic compounds present in plants or fruits. The aim of the present work was to investigate the in vitro effect of hexane, acetone, methanolic, and aqueous extracts of soursop leaves (Annona muricata L.) on the growth, motility, and biofilm formation of Lactobacillus casei, and to determine compounds related to growth. The minimum concentration promoting growth, motility (swimming, swarming, and twitching), and biofilm-forming capacity (crystal violet) were evaluated. The results showed the growth-promoting capacity of acetone and aqueous extracts at low doses 25–50 mg/L, and an inhibition in the four extracts at higher doses of 100 mg/L. The L. casei growth is related to ellagic acid, quercetin rhamnoside, kaempferol dihexoside, quercetin hexoside, secoisolariciresinol, and kaempferol hexoside-rhamnoside. Hexane extract increased the three types of motility, while aqueous maintained swimming and twitching motility similar to control. The four extracts inhibited the biofilm formation capacity."

prebiotic, Lactobacillus, polyphenol, probiotic, growth promoters, soursop leaves CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA CIENCIAS AGRARIAS AGROQUÍMICA REGULADORES DEL CRECIMIENTO DE LAS PLANTAS REGULADORES DEL CRECIMIENTO DE LAS PLANTAS

CuO-NPs Improve Biosynthesis of Bioactive Compounds in Lettuce

JAZMIN MONTSERRAT GAUCIN DELGADO Luis Guillermo Hernández Montiel Manuel Fortis Hernández JUAN JOSE REYES PEREZ José Antonio González Fuentes Pablo Preciado Rangel (2022, [Artículo])

"The application of metallic nanoparticles improves the yield and content of bioactive compounds in plants. The aim of the present study was to determine the effects of the foliar application of copper nanoparticles (CuO-NPs) in the yield and content of bioactive compounds in lettuce. Different concentrations of CuO-NPs (0, 0.5, 1, 2, 4, and 6 mg mL−1 ) were applied in lettuce. The yield, nutraceutical quality, and enzymatic activity were determined. Foliar spraying of CuO-NPs induced an increase in the biosynthesis of bioactive compounds. In addition to an increase in the activity of the enzymes superoxide dismutase (SOD) and catalase (CAT) in lettuce plants, there were no negative effects on yield. Therefore, with the application of CuO-NPs, better quality lettuces are produced for the human diet due to the higher production of bioactive compounds."

nano-biofortification, nanoparticles, antioxidants, Lactuca sativa L. CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA CIENCIAS AGRARIAS AGROQUÍMICA REGULADORES DEL CRECIMIENTO DE LAS PLANTAS REGULADORES DEL CRECIMIENTO DE LAS PLANTAS

Offshore wind energy climate projection using UPSCALE climate data under the RCP8.5 emission scenario

MARKUS SEBASTIAN GROSS (2016, [Artículo])

In previous work, the authors demonstrated how data from climate simulations can be utilized to estimate regional wind power densities. In particular, it was shown that the quality of wind power densities, estimated from the UPSCALE global dataset in offshore regions of Mexico, compared well with regional high resolution studies. Additionally, a link between surface temperature and moist air density in the estimates was presented. UPSCALE is an acronym for UK on PRACE (the Partnership for Advanced Computing in Europe)-weather-resolving Simulations of Climate for globAL Environmental risk. The UPSCALE experiment was performed in 2012 by NCAS (National Centre for Atmospheric Science)- Climate, at the University of Reading and the UK Met Office Hadley Centre. The study included a 25.6-year, five-member ensemble simulation of the HadGEM3 global atmosphere, at 25km resolution for present climate conditions. The initial conditions for the ensemble runs were taken from consecutive days of a test configuration. In the present paper, the emphasis is placed on the single climate run for a potential future climate scenario in the UPSCALE experiment dataset, using the Representation Concentrations Pathways (RCP) 8.5 climate change scenario. Firstly, some tests were performed to ensure that the results using only one instantiation of the current climate dataset are as robust as possible within the constraints of the available data. In order to achieve this, an artificial time series over a longer sampling period was created. Then, it was shown that these longer time series provided almost the same results than the short ones, thus leading to the argument that the short time series is sufficient to capture the climate. Finally, with the confidence that one instantiation is sufficient, the future climate dataset was analysed to provide, for the first time, a projection of future changes in wind power resources using the UPSCALE dataset. It is hoped that this, in turn, will provide some guidance for wind power developers and policy makers to prepare and adapt for climate change impacts on wind energy production. Although offshore locations around Mexico were used as a case study, the dataset is global and hence the methodology presented can be readily applied at any desired location. © Copyright 2016 Gross, Magar. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reprod

atmosphere, climate change, Europe, Mexico, sampling, time series analysis, university, weather, wind power, climate, risk, theoretical model, wind, Climate, Models, Theoretical, Risk, Wind CIENCIAS FÍSICO MATEMÁTICAS Y CIENCIAS DE LA TIERRA CIENCIAS DE LA TIERRA Y DEL ESPACIO OCEANOGRAFÍA OCEANOGRAFÍA