Título

Approaches in Polymeric Nanoparticles for Vaginal Drug Delivery: A Review of the State of the Art

Autor

GERARDO LEYVA GOMEZ

ELIZABETH PIÑON SEGUNDO

NESTOR MENDOZA MUÑOZ

MARIA DE LA LUZ ZAMBRANO ZARAGOZA

SUSANA ELISA MENDOZA ELVIRA

DAVID QUINTANAR GUERRERO

Nivel de Acceso

Acceso Abierto

Licencia

http://creativecommons.org/licenses/by/4.0

Identificador alterno

isni/0000 0004 0428 7635

Materias

MEDICINA Y CIENCIAS DE LA SALUD - (CTI) Vagina - (LEM) nanoparticles

Resumen o descripción

The vagina is a region of administration with a high contact surface to obtain local or systemic effects. This anatomical area represents special interest for government health systems for different sexually transmitted infections. However, the chemical changes of the vagina, as well as its abundant mucus in continuous exchange, act as a barrier and a challenge for the development of new drugs. For these purposes, the development of new pharmaceutical forms based on nanoparticles has been shown to offer various advantages, such as bioadhesion, easy penetration of the mucosa, and controlled release, in addition to decreasing the adverse effects of conventional pharmaceutical forms. In order to obtain nanoparticles for vaginal administration, the use of polymers of natural and synthetic origin including biodegradable and non-biodegradable systems have gained great interest both in nanospheres and in nanocapsules. The main aim of this review is to provide an overview of the development of nanotechnology for vaginal drug release, analyzing the different compositions of polymeric nanoparticles, and emphasizing new trends in each of the sections presented. At the end of this review, a section analyzes the properties of the vehicles employed for the administration of nanoparticles and discusses how to take advantage of the properties that they offer. This review aims to be a reference guide for new formulators interested in the vaginal route.

Editor

International Journal of Molecular Sciences

Fecha de publicación

23 de mayo de 2018

Tipo de publicación

Artículo

Recurso de información

http://biblos.ucol.mx//handle/123456789/123

Idioma

Inglés

Repositorio Orígen

Repositorio institucional de la Universidad de Colima

Descargas

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