Título
Association between nonalcoholic fatty liver disease and severe male reproductive organ impairment (Germinal Epithelial Loss): Study on a mouse model and on human patients
Autor
URIEL ALEJANDRO LOPEZ LEMUS
RAQUEL GARZA GUAJARDO
ORALIA BARBOZA QUINTANA
ALEJANDRINA RODRIGUEZ HERNANDEZ
José Guzmán Esquivel
ALEJANDRO GARCÍA RIVERA
VIOLETA M. MADRIGAL PÉREZ
LAURA ELVIRA GARCÍA LABASTIDA
ALEJANDRO DAVID SORIANO HERNANDEZ
MARGARITA DE LA LUZ MARTINEZ FIERRO
IRAM PABLO RODRIGUEZ SANCHEZ
ELIZABETH SANCHEZ DUARTE
ARIANA CABRERA LICONA
GABRIEL CEJA ESPIRITU
IVAN DELGADO ENCISO
Nivel de Acceso
Acceso Abierto
Identificador alterno
isni/0000 0004 0428 7635
Materias
Resumen o descripción
Metabolic syndrome (MS) has been associated with testicular damage. Nonalcoholic fatty liver disease (NAFLD) is a multisystemic disease that affects different organs, but its effect on the testes is unknown. A study analyzing germ cell involvement on BALB/c mice was carried out. A parallel comparative study was conducted that investigated alterations in the germinal epithelium of male humans that died from an unrelated acute event. The complete medical histories and histologic samples of the thoracic aorta, liver tissue, and testicular tissue from the deceased subjects were collected. The degree of germinal epithelial loss (DGEL) was evaluated and the clinical and histologic data were compared between individuals with and without NAFLD. The only metabolic or morphologic variable that caused a significant difference in the DGEL, in both the animal model and humans, was the presence of liver steatosis. The percentage of steatosis was also correlated with the percentage of the DGEL. In humans, steatosis (greater than 20%) increased the risk 12-fold for presenting with a severe DGEL (OR: 12.5; 95% CI [1.2, 128.9]; p = .03). There was no association with age above 50 years or MS components. Steatosis grade was also correlated with atherosclerosis grade. NAFLD was a strongly associated factor implicated in severe DGEL, as well as the testis was identified as a probable target organ for damage caused by the disease. his finding could result in the search for new approach strategies in the management of men with fertility problems. Further studies are required to confirm these results.
Editor
American Journal of Men’s Health
Fecha de publicación
26 de marzo de 2018
Tipo de publicación
Artículo
Recurso de información
Idioma
Inglés
Repositorio Orígen
Repositorio institucional de la Universidad de Colima
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