Título

Histological changes caused by meclofenamic acid in androgen independent prostate cancer tumors: evaluation in a mouse model

Autor

IVAN DELGADO ENCISO

LAURA LETICIA VALDEZ VELAZQUEZ

JOSE GUZMAN ESQUIVEL

ALEJANDRINA RODRIGUEZ HERNANDEZ

HECTOR RAFAEL GALVAN SALAZAR

ALEJANDRO DAVID SORIANO HERNANDEZ

DANIEL ALBERTO MONTES GALINDO

RAFAEL MARTINEZ MARTINEZ

RAFAEL GONZALEZ ALVAREZ

FRANCISCO ESPINOZA GOMEZ

OSCAR ALBERTO NEWTON SANCHEZ

AGUSTIN LARA ESQUEDA

Nivel de Acceso

Acceso Abierto

Licencia

http://creativecommons.org/licenses/by/4.0

Materias

MEDICINA Y CIENCIAS DE LA SALUD - (CTI) Prostatic-Neoplasms - (SIN FUENTE) Próstata-Neoplasmas - (LEMB) Meclofenamic Acid - (SIN FUENTE) Therapeutics - (LEMB) Terapéutica - (LEMB) Anti-Inflammatory Agents - (LEMB) Agentes anti-inflamatorios - (LEMB)

Resumen o descripción

"The objective of the present work was to analyze the histological changes caused by meclofenamic acid in androgen-independent rostate cancer. Tumors were created in a nude mouse model using PC3 cancerous human cells. Meclofenamic acid (10 mg/kg/day; experimental group, n=5) or saline solution (control group, n=5) was administered intraperitoneally for twenty days. Histological analysis was then carried out on the tumors,

describing changes in the cellular architecture, fibrosis, and quantification of cellular proliferation and tumor vasculature. Meclofenamic acid causes histological changes that indicate less tumor aggression (less hypercellularity, fewer atypical mitoses, and fewer nuclear polymorphisms), an increase in fibrosis, and reduced cellular proliferation and tumor vascularity."

Editor

BRAZILIAN SOC UROL

Fecha de publicación

septiembre de 2015

Tipo de publicación

Artículo

Recurso de información

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756978/

Idioma

Inglés

Repositorio Orígen

Repositorio institucional de la Universidad de Colima

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