Título

Mechanochemical synthesis and crystal structure of the lidocaine-phloroglucinol hydrate 1:1:1 complex

Autor

NANCY EVELYN MAGAÑA VERGARA

PORFIRIO DE LA CRUZ CRUZ

ANA LILIA PERAZA CAMPOS

FRANCISCO JAVIER MARTINEZ MARTINEZ

JUAN SAULO GONZALEZ GONZALEZ

Nivel de Acceso

Acceso Abierto

Licencia

http://creativecommons.org/licenses/by/4.0

Identificador alterno

isni/0000 0004 0483 9065

Materias

BIOLOGÍA Y QUÍMICA - (CTI) Lidocaine - (LCSH) Phloroglucinol - (SIN FUENTE) Crystal structure - (SIN FUENTE) Hydrogen bonding - (LCSH) Hydration - (LCSH) Molecular complex - (SIN FUENTE)

Resumen o descripción

Molecular complexation is a strategy used to modify the physicochemical or biopharmaceutical properties of an active pharmaceutical ingredient. Solvent assisted grinding is a common method used to obtain solid complexes in the form of cocrystals. Lidocaine is a drug used as an anesthetic and for the treatment of chronic pain, which bears in its chemical structure an amide functional group able to form hydrogen bonds. Polyphenols are used as cocrystal coformers due to their ability to form O–H···X (X = O, N) hydrogen bond interactions. The objective of this study was to exploit the ability of phloroglucinol to form molecular complexes with lidocaine by liquid assisted grinding. The formation of the complex was confirmed by the shift of the O–H and C=O stretching bands in the IR spectra of the polycrystalline ground powders, suggesting the formation of O–H···O=C hydrogen bonds. Hydration of the complexes also was confirmed by IR spectroscopy and by powder X-ray diffraction. The molecular structure was determined by single crystal X-ray diffraction.

Editor

Crystals de MDPI

Fecha de publicación

9 de marzo de 2018

Tipo de publicación

Artículo

Recurso de información

http://biblos.ucol.mx//handle/123456789/92

Idioma

Inglés

Repositorio Orígen

Repositorio institucional de la Universidad de Colima

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