Título
HYPOCHOLESTEROLEMIC EFFECT AND IN VITRO PANCREATIC LIPASE INHIBITORY ACTIVITY OF AN OPUNTIA FICUS.INDICA EXTRAC
Autor
EDUARDO PADILLA CAMBEROS
Colaborador
CARLOS MENDEZ CARRETO (Colaborador)
FABIOLA SANDOVAL SALAS (Colaborador)
JOSE MIGUEL FLORES FERNANDEZ (Colaborador)
Nivel de Acceso
Acceso Abierto
Referencia de publicación
doi: http://dx.doi.org/10.1155/2015/837452
Materias
Resumen o descripción
Cholesterol control is fundamental for prevention of cardiovascular disorders. In this work, the hypocholesterolemic activity of an
aqueous Opuntia ficus-indica extract (AOE) was tested in triton-induced mice. The inhibitory activity on pancreatic lipase enzyme
was evaluated in vitro by the same extract. Furthermore, polyphenol content of the extract was evaluated. Hypercholesterolemia
was induced in three groups of mice by intraperitoneal administration of TritonWR-1339. After induction of hypercholesterolemia,
the groups were treated with an AOE (500mg/kg) and saline solution and the positive control group with orlistat, respectively.
Cholesterol levels were measured 24 h later in peripheral blood. The levels of blood cholesterol after administration of AOE
significantly decreased compared to negative control. The inhibitory activity of AOE on pancreatic lipase enzyme was evaluated
at concentrations from 60 to 1000 𝜇g/mL. The AOE inhibited the pancreatic lipase with an IC50 = 588.5 𝜇g/mL. The AOE had a
high content of polyphenolic compounds. These results show that AOE is able to prevent hypercholesterolemia by pancreatic lipase
inhibition, in part due to its polyphenolic compounds.
Editor
HINDAWI PUBLISHING CORPORATION
Fecha de publicación
2015
Tipo de publicación
Artículo
Recurso de información
Formato
application/pdf
Fuente
HINDAWI PUBLISHING CORPORATION THE SCIENTIFIC WORLD JOURNAL, VOLUMEN 2015
Idioma
Inglés
Relación
&
Allen, K. (2015). Hypocholesterolemic effect and in vitro pancreatic lipase inhibitory activity of an Opuntia ficus-indica extract. BioMed research international, 2015.
Audiencia
Investigadores
Sugerencia de citación
Padilla-Camberos, E., Flores-Fernandez, J. M., Fernandez-Flores, O., Gutierrez-Mercado, Y., Carmona-de la Luz, J., Sandoval-Salas, F., ...
Repositorio Orígen
Repositorio Institucional de CIATEJ
Descargas
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