Título
Wound healing and antoxidant capacity of Musa paradisiaca Linn. Peel extracts
Autor
Eduardo Padilla Camberos
JOSE MIGUEL FLORES FERNANDEZ
Alejandro Arturo Canales Aguirre
CARLA PATRICIA BARRAGAN ALVAREZ
Yanet Karina Gutiérrez Mercado
EUGENIA DEL CARMEN LUGO CERVANTES
Nivel de Acceso
Acceso Abierto
Referencia de datos
datasetURL/http://jppres.com/jppres/pdf/vol4/jppres16.124_4.5.165.pdf
Resumen o descripción
"Context: Musa paradisiaca has several biological activities within them wound healing, hypoglycemic, hepatoprotective, antimicrobial,
antioxidant, among others. However, these properties in peel have been poorly explored. Aims: Evaluate the wound healing activity induced by an incision wound model using methanolic, hexanoic and chloroformic extracts from M. paradisiaca peel.
Methods: Dehydrated M. paradisíaca peel was mixed with methanol, hexane, and chloroform. The presence of bioactive substances of the M. paradisiaca peel extracts was carried out by the Trease and Evans methods. Antioxidant capacity was evaluated by the 2,2-diphenyl-2- picrylhydrazyl (DPPH) method. Acute toxicity was realized according to up and down OECD procedure in BALB/c mice. Wound healing activity was evaluated in male Wistar rats. Histological analyses of tissues were made by microscopy using staining methods of hematoxylin and eosin and Masson-trichrome.
Results: Treated groups with methanolic and hexanoic extracts of M. paradisiaca peel showed better wound healing activity in comparison with the group treated with chloroformic extract, with an inhibition of DPPH radical bleaching of 89-90%. It may be due to the presence of alkaloids, tannins, saponins and phenols as principal constituents by conferring antioxidant capacity. The extract did not induce any toxicity.
Conclusions: The findings showed the wound healing and antioxidant capacity of M. paradisiaca peel extract. It was observed that depending on the extraction solvent; there is a variation in the antioxidant capacity that also affects the effectiveness of the restoration of tissue, suggesting that the antioxidant capacity could play a major role in the process of wound healing".
Editor
JPPRes
Fecha de publicación
2016
Tipo de publicación
Artículo
Recurso de información
Formato
application/pdf
Fuente
Journal of Pharmacy
&
Pharmacognosy Research, 4 (5), 165-173
Idioma
Inglés
Sugerencia de citación
Padilla-Camberos E, Flores-Fernández JM, Canales-Aguirre AA, Barragán-Álvarez CP, Gutiérrez-Mercado Y, Lugo-Cervantes E (2016) Wound healing and antioxidant capacity of Musa paradisiaca Linn. peel extracts. J Pharm Pharmacogn Res 4(5): 165-173.
Repositorio Orígen
Repositorio Institucional de CIATEJ
Descargas
549