Título
Production of plant secondary metabolites: Examples, tips and suggestions for biotechnologists
Autor
Gea Guerriero
Roberto Berni
JOSE ARMANDO MUÑOZ SANCHEZ
Fabio Apone
Eslam Abdel_Salam
Abdulhakim Qahtan
Abdulrahman A. Alatar
CLAUDIO CANTINI
Giampiero Cai
Jean-Francois Hausman
Khawar Siddiqui
SOLEDAD MARIA TERESA HERNANDEZ SOTOMAYOR
Mohammed Faisal
Nivel de Acceso
Acceso Abierto
Referencia de datos
datasetDOI/10.3390/genes9060309
Materias
Resumen o descripción
Plants are sessile organisms and, in order to defend themselves against exogenous (a)biotic constraints, they synthesize an array of secondary metabolites which have important physiological and ecological effects. Plant secondary metabolites can be classified into four major classes: terpenoids, phenolic compounds, alkaloids and sulphur-containing compounds. These phytochemicals can be antimicrobial, act as attractants/repellents, or as deterrents against herbivores. The synthesis of such a rich variety of phytochemicals is also observed in undifferentiated plant cells under laboratory conditions and can be further induced with elicitors or by feeding precursors. In this review, we discuss the recent literature on the production of representatives of three plant secondary metabolite classes: artemisinin (a sesquiterpene), lignans (phenolic compounds) and caffeine (an alkaloid). Their respective production in well-known plants, i.e., Artemisia, Coffea arabica L., as well as neglected species, like the fibre-producing plant Urtica dioica L., will be surveyed. The production of artemisinin and caffeine in heterologous hosts will also be discussed. Additionally, metabolic engineering strategies to increase the bioactivity and stability of plant secondary metabolites will be surveyed, by focusing on glycosyltransferases (GTs). We end our review by proposing strategies to enhance the production of plant secondary metabolites in cell cultures by inducing cell wall modifications with chemicals/drugs, or with altered concentrations of the micronutrient boron and the quasi-essential element silicon.
Fecha de publicación
2018
Tipo de publicación
Artículo
Versión de la publicación
Versión publicada
Recurso de información
Formato
application/pdf
Fuente
Genes, 9(6), 309, 2018.
Idioma
Inglés
Relación
&
Siddiqui, K. (2018). Production of plant secondary metabolites: Examples, tips and suggestions for biotechnologists. Genes, 9(6), 309.
Sugerencia de citación
Guerriero, G., Berni, R., Muñoz-Sanchez, J., Apone, F., Abdel-Salam, E., Qahtan, A., ...
Repositorio Orígen
Repositorio Institucional CICY
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