Título
HLA-C genotype and TCR vβ expression analysis in Mexican patients with Psoriasis
Autor
MARTHA LETICIA SANTOS MARTINEZ
Ma. Fabiola León Galván
ERIKA NAHOMY MARINO MARMOLEJO
Antonio de León Rodríguez
Ana Paulina Barba de la Rosa
BENJAMIN MONCADA GONZALEZ
Nivel de Acceso
Acceso Abierto
Identificador alterno
doi: https://doi.org/10.2478/s11536-011-0038-9
Materias
Resumen o descripción
"Genetic background and T-cell expansion have been associated as the most important factors for psoriasis susceptibility in the Caucasian population. This study was performed to identify the T cell receptor Vβ repertoire and HLA-Cw genotype in two Mexican groups with severe chronic plaque-type psoriasis. HLA-C typing was performed to detect the allele pattern associated with the disease by sequence-specific primer-polymerase chain reaction. In parallel, RT-PCR and Western blot were used for the identification of the TCR Vβ repertoire. We found a wide variety of HLA-C alleles displayed with a preference to HLA-Cw *07 as the most representative allele in the group of patients. TCR Vβ-2 and Vβ-7 clone-type frequencies were statistically significant (p of 0.0280) when compared to other TCR Vβ expressed in the two groups. We found notable differences both in the HLA-C genotype and TCR Vβ repertoire in the groups of patients studied. Since Mexican individuals are genetically different from the Caucasian population, we suggest that due to these differences the susceptibility to disease and activation of T-cells for a proper immune response may be affected."
Editor
Springer
Fecha de publicación
2011
Tipo de publicación
Artículo
Versión de la publicación
Versión enviada
Recurso de información
Formato
application/pdf
Sugerencia de citación
Santos, L., León-Galvan, M.F., Fuentes-Ahumada, C. et al. cent.eur.j.med (2011) 6: 442. https://doi.org/10.2478/s11536-011-0038-9
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