Título
Phylogeography and Genetic Variation of Triatoma dimidiata, the Main Chagas Disease Vector in Central America, and Its Position within the Genus Triatoma.
Autor
Maria Dolores Bargues
Rocío Klisiowicz
Fernando Gonzalez-Candelas
Janine Ramsey
Maria Carlota Monroy Escobar
Carlos Ponce
Paz Maria Silvia Salazar Schettino
Francisco Panzera Arballo
Fernando Abad
Octavio Sousa
Christopher Schofield
Jean Pierre Dujardin
Felipe Guhl
Santiago Mas-Coma
Nivel de Acceso
Acceso Abierto
Identificador alterno
doi: https://doi.org/10.1371/journal.pntd.0000233
Materias
Haplotipos - ([PLoS Neglected Tropical Diseases (1935-2735) vol. 2(5), 1-19 (2008)]) Triatoma - ([PLoS Neglected Tropical Diseases (1935-2735) vol. 2(5), 1-19 (2008)]) Genética de poblaciones - ([PLoS Neglected Tropical Diseases (1935-2735) vol. 2(5), 1-19 (2008)]) Polimorfismo genético - ([PLoS Neglected Tropical Diseases (1935-2735) vol. 2(5), 1-19 (2008)]) Filogeografía - ([PLoS Neglected Tropical Diseases (1935-2735) vol. 2(5), 1-19 (2008)]) BIOLOGÍA Y QUÍMICA - (CTI)
Resumen o descripción
BACKGROUND: Among Chagas disease triatomine vectors, the largest genus, Triatoma, includes species of high public health interest. Triatoma dimidiata, the main vector throughout Central America and up to Ecuador, presents extensive phenotypic, genotypic, and behavioral diversity in sylvatic, peridomestic and domestic habitats, and non-domiciliated populations acting as reinfestation sources. DNA sequence analyses, phylogenetic reconstruction methods, and genetic variation approaches are combined to investigate the haplotype profiling, genetic polymorphism, phylogeography, and evolutionary trends of T. dimidiata and its closest relatives within Triatoma. This is the largest interpopulational analysis performed on a triatomine species so far. METHODOLOGY AND FINDINGS: Triatomines from Mexico, Guatemala, Honduras, Nicaragua, Panama, Cuba, Colombia, Ecuador, and Brazil were used. Triatoma dimidiata populations follow different evolutionary divergences in which geographical isolation appears to have had an important influence. A southern Mexican-northern Guatemalan ancestral form gave rise to two main clades. One clade remained confined to the Yucatan peninsula and northern parts of Chiapas State, Guatemala, and Honduras, with extant descendants deserving specific status. Within the second clade, extant subspecies diversity was shaped by adaptive radiation derived from Guatemalan ancestral populations. Central American populations correspond to subspecies T. d. dimidiata. A southern spread into Panama and Colombia gave the T. d. capitata forms, and a northwestern spread rising from Guatemala into Mexico gave the T. d. maculipennis forms. Triatoma hegneri appears as a subspecific insular form. CONCLUSIONS: The comparison with very numerous Triatoma species allows us to reach highly supported conclusions not only about T. dimidiata, but also on different, important Triatoma species groupings and their evolution. The very large intraspecific genetic variability found in T. dimidiata sensu lato has never been detected in a triatomine species before. The distinction between the five different taxa furnishes a new frame for future analyses of the different vector transmission capacities and epidemiological characteristics of Chagas disease. Results indicate that T. dimidiata will offer problems for control, although dwelling insecticide spraying might be successful against introduced populations in Ecuador.
Editor
Public Library of Science
Fecha de publicación
2008
Tipo de publicación
Artículo
Versión de la publicación
Versión publicada
Recurso de información
Formato
application/pdf
Fuente
PLoS Neglected Tropical Diseases (1935-2735) vol. 2(5), 1-19 (2008)
Idioma
Inglés
Relación
https://www.ncbi.nlm.nih.gov/pmc/issues/164613/
Cobertura
US
Repositorio Orígen
Repositorio Institucional de la Facultad de Medicina,UNAM.Departamento de Microbiologia y Parasitologia
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