Título
The Mechanobiology of the Actin Cytoskeleton in Stem Cells during Differentiation and Interaction with Biomaterials.
Autor
Xochitl Ambriz Peña
Primal de Lanerolle
Javier Rolando Ambrosio Hernandez
Nivel de Acceso
Acceso Abierto
Identificador alterno
doi: https://doi.org/10.1155/2018/2891957
Materias
Células troncales mesenquimales humanas - ([Stem Cell International (16879678) vol. 10(1), (42-47), (2019)]) Actina - ([Stem Cell International (16879678) vol. 10(1), (42-47), (2019)]) Diferenciación - ([Stem Cell International (16879678) vol. 10(1), (42-47), (2019)]) Biomateriales - ([Stem Cell International (16879678) vol. 10(1), (42-47), (2019)]) BIOLOGÍA Y QUÍMICA - (CTI)
Resumen o descripción
An understanding of the cytoskeleton’s importance in stem cells is essential for their manipulation and further clinical application. The cytoskeleton is crucial in stem cell biology and depends on physical and chemicals signals to define its structure. Additionally, cell culture conditions will be important in the proper maintenance of stemness, lineage commitment, and differentiation. This review focuses on the following areas: the role of the actin cytoskeleton of stem cells during differentiation, the significance of cellular morphology, signaling pathways involved in cytoskeletal rearrangement in stem cells, and the mechanobiology and mechanotransduction processes implicated in the interactions of stem cells with different surfaces of biomaterials, such as nanotopography, which is a physical cue influencing the differentiation of stem cells. Also, cancer stem cells are included since it is necessary to understand the role of their mechanical properties to develop new strategies to treat cancer. In this context, to study the stem cells requires integrated disciplines, including molecular and cellular biology, chemistry, physics, and immunology, as well as mechanobiology. Finally, since one of the purposes of studying stem cells is for their application in regenerative medicine, the deepest understanding is necessary in order to establish safety protocols and effective cell-based therapies.
Editor
Hindawi
Fecha de publicación
2019
Tipo de publicación
Artículo
Versión de la publicación
Versión publicada
Recurso de información
Formato
application/pdf
Fuente
Stem Cell International (16879678) vol. 10(1), (42-47), (2019)
Idioma
Inglés
Relación
https://www.hindawi.com/journals/sci/2018/
Cobertura
EG
Repositorio Orígen
Repositorio Institucional de la Facultad de Medicina,UNAM.Departamento de Microbiologia y Parasitologia
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