Author: BLANCA MARINA VERA KU

Phytochemical and pharmacological studies on species of Dorstenia genus (2000-2016)

HECTOR ARTURO PENICHE PAVIA BLANCA MARINA VERA KU SERGIO RUBEN PERAZA SANCHEZ (2018)

The main objective of this review is to update the current knowledge on species of Dorstenia genus. Previous review was published in 2000. This genus includes 117 accepted named species, from which metabolites with a great variety of structures are found. In the last fifteen years, a blooming has occurred in the research of the genus, with more than 60 original research papers on the chemistry and pharmacology of many species, being one of the main reasons to this thriving the generalized use of Dorstenia species in the traditional medicine around the world.

Article

PHYTOCHEMISTRY AND PHARMACOLOGY DORSTENIA COUMARINS TERPENES FLAVONOIDS BIOLOGÍA Y QUÍMICA BIOLOGÍA Y QUÍMICA

Antileishmanial activity of a mixture of Tridax procumbens and Allium sativum in mice

Activité antileishmaniale d'un mélange de Tridax procumbens et Allium sativum chez la souris

MIRIAM RUBI DE LOS MILAGROS GAMBOA LEON BLANCA MARINA VERA KU SERGIO RUBEN PERAZA SANCHEZ CARLOS ALBERTO KU CHULIM AURELIO HORTA BAAS MIGUEL ENRIQUE ROSADO VALLADO (2014)

We tested a mixture of Tridax procumbens, known for its direct action against Leishmania mexicana, and Allium sativum, known for its immunomodulatory effect, as an alternative to treat cutaneous leishmaniasis. Acute oral toxicity was tested with the Up-and-Down Procedure (UDP) using a group of healthy mice administered with either T. procumbens or A. sativum extracts and compared with a control group. Liver injury and other parameters of toxicity were determined in mice at day 14. The in vivo assay was performed with mice infected with L. mexicana promastigotes and treated with either a mixture of T. procumbens and A. sativum or each extract separately. The thickness of the mice's footpads was measured weekly. After the 12-week period of infection, blood samples were obtained by cardiac puncture to determine the total IgG, IgG1 and IgG2a immunoglobulins by a noncommercial indirect ELISA. We showed that the mixture of T. procumbens and A. sativum extracts was better at controlling L. mexicana infection while not being toxic when tested in the acute oral toxicity assay in mice. An increase in the ratio of IgG2a/IgG1 indicated a tendency to raise a Th1-type immune response in mice treated with the mixture. The mixture of T. procumbens and A. sativum extracts is a promising natural treatment for cutaneous leishmaniasis and its healing effects make it a good candidate for a possible new phytomedicine.

Article

LEISHMANICIDAL ACTIVITY TRIDAX PROCUMBENS ALLIUM SATIVUM ACUTE ORAL TOXICITY PHYTOMEDICINE BIOLOGÍA Y QUÍMICA