Título
A single neonatal administration of Bisphenol A induces higher tumour weight associated to changes in tumour microenvironment in the adulthood
Autor
MARGARITA ISABEL PALACIOS ARREOLA
KAREN ELIZABETH NAVA CASTRO
VICTOR HUGO DEL RIO ARAIZA
NASHLA YAZMIN PEREZ SANCHEZ
JORGE MORALES MONTOR
Nivel de Acceso
Acceso Abierto
Identificador alterno
doi: 10.1038/s41598-017-10135-1
Referencia de publicación
URL/https://www.nature.com/articles/s41598-017-10135-1
Resumen o descripción
BPA is an oestrogenic endocrine disrupting chemical compound. Exposure to BPA in as early as pregnancy leads to lifelong effects. Since endocrine and immune systems interact in a bidirectional manner, endocrine disruption may cause permanent alterations of the immune system, affecting a future anti-tumoral response. Neonate (PND 3) female syngeneic BALB/c mice were exposed to a single dose of 250 µg/kg BPA. Once sexual maturity was reached, a mammary tumour was induced injecting 4T1 cells in situ, these cells are derived from a spontaneous adenocarcinoma in a BALB/c mouse and therefore allows for an immunocompetent recipient. After 25 days of injection, showing no major endocrine alterations, BPA-exposed mice developed larger tumours. Tumour leukocytic infiltrate analysis revealed a higher proportion of regulatory T lymphocytes in the BPA-exposed group. RT-PCR analysis of tumour samples showed a decreased expression of TNF-α and IFN-γ, as well as the M2 macrophage marker Fizz-1 in the BPA-exposed group. Flow cytometry analysis revealed differences in ERα expression by T lymphocytes, macrophages and NK cells, both associated to BPA exposure and tumour development. These findings show a new aspect whereby early life BPA exposure can contribute to breast cancer development and progression by modulating the anti-tumoral immune response.
Editor
Nature Publishing Group
Fecha de publicación
5 de septiembre de 2017
Tipo de publicación
Artículo
Versión de la publicación
Versión publicada
Recurso de información
Formato
application/pdf
Fuente
Sci Rep-Uk
ISSN: 2045-2322
Idioma
Inglés
Audiencia
Investigadores
Estudiantes
Repositorio Orígen
Repositorio Institucional del Centro de Ciencias de la Atmósfera de la UNAM
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