Título
Antituberculosis activity of alkylated mulinane diterpenoids
Autor
LUIS MANUEL PEÑA RODRIGUEZ
Nivel de Acceso
Acceso Abierto
Resumen o descripción
Natural azorellane and mulinane diterpenoids show antituberculosis activity, which is
increased by methylation of their free carboxyl group. We have systematically investigated
the effect of alkylation in this class of diterpenoids and found that the profile of bioactivity is
relatively unaffected by the introduction of short alkyl groups, both linear and branched. In this
investigation, three semisynthetic diterpenoids, 13 hydroxy-mulin-11-en-20-oic acid n-propyl
ester (3) and the n-propyl (19) and n-butyl (20) esters of isomulinic acid, showed the
strongest antituberculosis activity (MIC =6.25 μg/mL) against a drug-resistant strain of
Mycobacterium tuberculosis.
Fecha de publicación
4 de abril de 2010
Tipo de publicación
Artículo
Recurso de información
Formato
application/pdf
Idioma
Inglés
Repositorio Orígen
Repositorio Institucional CICY
Descargas
543