Título
Bioactive metabolites from the Andean flora. Antituberculosis activity of natural and semisynthetic azorellane and mulinane diterpenoids
Autor
LUIS MANUEL PEÑA RODRIGUEZ
Nivel de Acceso
Acceso Abierto
Resumen o descripción
Natural products are recognized as an
important source of new and better pharmaceuticals
for the treatment of diseases such as tuberculosis. The
azorellane and mulinane diterpenoids represent an
interesting group of bioactive metabolites produced
by Andean plants belonging to the Azorella, Mulinum,
Laretia and Bolax genus. Testing of natural and
semisynthetic azorellanes and mulinanes against two Mycobacterium tuberculosis strains showed that
while most changes in the structure of the natural
metabolites result in the loss of antituberculosis
activity, methylation of the C-20 carboxyl group
improves the biological activity of the corresponding
derivatives.
Fecha de publicación
1 de febrero de 2010
Tipo de publicación
Artículo
Recurso de información
Formato
application/pdf
Idioma
Inglés
Repositorio Orígen
Repositorio Institucional CICY
Descargas
776